Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker
Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker
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消化道癌中的长非编码 RNA：功能、机制和潜在生物标志物
DOI：
10.1634/theoncologist.2014-0475
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发表时间：
2015-08-01
期刊：
影响因子：
5.8
通讯作者：
Li, Bo-Sheng
中科院分区：
文献类型：
--
作者：
Zeng, Shuo;Xiao, Yu-Feng;Li, Bo-Sheng
消化道癌 (DTC) 是全球癌症相关死亡的主要原因。目前针对晚期 DTC 的治疗工具存在局限性，早期 DTC 患者由于缺乏有效的生物标志物而经常漏诊。因此，有必要开发用于早期诊断的新生物标志物和用于治疗 DTC 的新治疗靶点。近年来，长非编码RNA（IncRNA），一类长度超过200个核苷酸的非编码RNA，已被证明在DTC中异常表达，并在DTC的发展中发挥重要作用：IncRNA的表达谱与DTC患者的不良生存密切相关，并且IncRNA在DTC进展中充当癌基因或抑癌基因。在这篇综述中，我们总结了功能性 IncRNA 并阐述了它们在 DTC 中的调控机制。
Digestive tract cancers (DTCs) are a leading cause of cancer-related death worldwide. Current therapeutic tools for advanced stage DTCs have limitations, and patients with early stage DTCs frequently have a missed diagnosis due to shortage of efficient biomarkers. Consequently, it is necessary to develop novel biomarkers for early diagnosis and novel therapeutic targets for treatment of DTCs. In recent years, long noncoding RNAs (IncRNAs), a class of noncoding RNAs with >200 nucleotides, have been shown to be aberrantly expressed in DTCs and to have an important role in DTC development: the expression profiles of IncRNAs strongly correlated with poor survival of patients with DTCs, and IncRNAs acted as oncogenes or tumor suppressor genes in DTC progression. In this review, we summarized the functional IncRNAs and expounded on their regulatory mechanisms in DTCs.