Mathematical Modeling of Plasticity and Heterogeneity in EMT.
Mathematical Modeling of Plasticity and Heterogeneity in EMT.
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DOI：
10.1007/978-1-0716-0779-4_28
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jolly MK
中科院分区：
文献类型：
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作者：
Tripathi S;Xing J;Levine H;Jolly MK
上皮-间质转化（EMT）和相应的逆过程，间质-上皮转化（MET），是由生化和形态水平上的许多变化精心策划的动态且可逆的细胞程序。最近，人们对 EMT/MET 分子机制的认识激增，导致了各种数学模型的发展，这些模型有助于我们更好地理解单细胞和群体水平的动力学：(a) 多重稳定性——在 EMT/MET 过程中细胞可以获得多少种表型？(b) 可逆性/不可逆性——EMT 诱导剂的什么时间和/或浓度标志着诱导经历 EMT 的细胞无法恢复的“临界点”？(c) 对称性EMT/MET——细胞在恢复时是否采取与诱导 EMT 期间相同的路径？（d）非细胞自主机制——经历 EMT 的细胞如何改变其邻近细胞经历 EMT 的倾向？这些动态特征可能促进经历 EMT/MET 的细胞群内的异质反应。在这里，我们提供了一些设计不同数学模型的示例，这些模型有助于解码 EMT/MET 动态。
The epithelial-mesenchymal transition (EMT) and the corresponding reverse process, mesenchymal-epithelial transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at both biochemical and morphological levels. A recent surge in identifying the molecular mechanisms underlying EMT/MET has led to the development of various mathematical models that have contributed to our improved understanding of dynamics at single-cell and population levels: (a) multi-stability—how many phenotypes can cells attain during an EMT/MET?, (b) reversibility/irreversibility—what time and/or concentration of an EMT inducer marks the “tipping point” when cells induced to undergo EMT cannot revert?, (c) symmetry in EMT/MET—do cells take the same path when reverting as they took during the induction of EMT?, and (d) non-cell autonomous mechanisms—how does a cell undergoing EMT alter the tendency of its neighbors to undergo EMT? These dynamical traits may facilitate a heterogenous response within a cell population undergoing EMT/MET. Here, we present a few examples of designing different mathematical models that can contribute to decoding EMT/MET dynamics.