Increased expression of MUC1 in advanced pancreatic cancer
Increased expression of MUC1 in advanced pancreatic cancer
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DOI：
10.1007/s00535-003-1224-6
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发表时间：
2003-12-01
影响因子：
6.3
通讯作者：
Yonezawa, S
中科院分区：
文献类型：
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作者：
Hinoda, Y;Ikematsu, Y;Yonezawa, S
背景MUC1与肿瘤侵袭和转移相关，在胰腺癌中高表达。本研究探讨了 MUC1 表达是否影响胰腺癌患者的生存。方法。使用抗 MUC1 单克隆抗体 DF3 对取自 70 名 pTNM III 期或 IV 期胰腺浸润性导管癌患者的组织标本进行免疫染色。当癌细胞总数50%以上呈阳性染色时，判定免疫染色结果为阳性。对 DF3 表位的表达与临床病理学参数或患者生存的关联进行统计评估。结果。 MUC1 表达阳性的发生率为 55.7% (39/70)，pTNM IV 期的阳性发生率显着高于 III 期（比值比 [OR]，4.015；95% 置信区间 [CI]，1.459-11.0541；P = 0.0076）。由于pTNM III期和IV期之间的总生存率存在明显差异（P = 0.0016），因此在每个阶段分别评估MUC1表达对生存的影响。结果表明，MUC1 的表达与 IV 期不利的总生存率相关（P = 0.0197）。结论。我们的数据表明MUC1的表达可能与胰腺癌的进展有关。
Background MUC1 is associated with tumor invasion and metastasis, and is expressed in pancreatic cancer with a high frequency. This study explored whether MUC1 expression affected the survival of patients with pancreatic cancer. Methods. Tissue specimens obtained from 70 patients with invasive ductal carcinoma of the pancreas, in pTNM stage III or IV, were immunostained with the anti-MUC1 monoclonal antibody DF3. The results of immunostaining were determined to be positive when more than 50% of the total cancer cells were positively stained. Association of the expression of the DF3 epitope with clinicopathological parameters or patients' survival was statistically evaluated. Results. The incidence of positivity of MUC1 expression was 55.7% (39/70) and this incidence was significantly higher in pTNM stage IV than in stage III (odds ratio [OR], 4.015; 95% confidence interval [CI], 1.459-11.0541.; P = 0.0076). As there was a clear difference in overall survival between pTNM stages III and IV (P = 0.0016), the effect of MUC1 expression on survival was separately evaluated in each stage. It was shown that the expression of MUC1 was associated with unfavorable overall survival in stage IV (P = 0.0197). Conclusions. Our data suggest that the expression of MUC1 may be related to the progression of pancreatic cancer.