Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design
Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design
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寨卡病毒单克隆抗体：治疗方法及其对疫苗设计的影响
DOI：
10.1128/jvi.01049-17
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发表时间：
2017-10-01
影响因子：
5.4
通讯作者：
Gao, George Fu
中科院分区：
文献类型：
--
作者：
Wang, Qihui;Yan, Jinghua;Gao, George Fu
寨卡病毒（ZIKV）因与新生儿和成人的神经系统并发症有关而引起了全球关注。尽管到目前为止，还没有针对寨卡病毒感染的疫苗或抗病毒药物获得批准，但在短时间内已经开发出了数百种单克隆抗体（MAb）。在此，我们首先全面介绍寨卡病毒单克隆抗体，然后重点关注通过结构研究揭示的中和机制和免疫热点，这为治疗方法和疫苗设计提供了思路。
ABSTRACT Zika virus (ZIKV) has caused global concern due to its association with neurological complications in newborns and adults. Although no vaccines or antivirals against ZIKV infection have been approved to date, hundreds of monoclonal antibodies (MAbs) have been developed in a short period. Here, we first present a complete picture of the ZIKV MAbs and then focus on the neutralizing mechanisms and immune hot spots uncovered through structural studies, which provide insight for therapeutics and vaccine design.