Magnetic Dehydrodipeptide-Based Self-Assembled Hydrogels for Theragnostic Applications
Magnetic Dehydrodipeptide-Based Self-Assembled Hydrogels for Theragnostic Applications
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DOI：
10.3390/nano9040541
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发表时间：
2019-04-01
期刊：
影响因子：
5.3
通讯作者：
Martins, Jose A.
中科院分区：
文献类型：
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作者：
Carvalho, Andre;Gallo, Juan;Martins, Jose A.
近年来，自组装肽水凝胶已成为生物材料研究的新范例。我们在该领域开发了基于萘普生封端的脱氢二肽的水凝胶。脱氢二肽水凝胶可负载药物，因此是潜在的药物递送纳米载体。在这项工作中，制备并表征了含有酪氨酸和天冬氨酸氨基酸残基且N端被萘普生封端、C端为脱氢苯丙氨酸的新型脱氢二肽。将超顺磁性氧化铁纳米粒子（SPIONs）掺入基于脱氢二肽的水凝胶中，并研究了它们对水凝胶的自组装、结构以及流变学和磁学性质的影响。掺入SPIONs的磁性水凝胶显示出浓度依赖性的T - 2 - MRI造影增强。此外，在磁激发（交变磁场 - AMF -）时，SPIONs能够产生大量热量。因此，磁热疗可作为释放自组装脱氢二肽水凝胶中药物负载和掺入的SPIONs的远程触发手段。
Self-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides N-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid amino acid residues N-capped with naproxen and C-terminal dehydrophenylalanine were prepared and characterized. Superparamagnetic iron oxide nanoparticles (SPIONs) were incorporated into the dehydrodipeptide-based hydrogels and their effect on the self-assembly, structure and rheological and magnetic properties of the hydrogels was studied. Magnetic hydrogels, with incorporated SPIONs, displayed concentration-dependent T-2-MRI contrast enhancement. Moreover, upon magnetic excitation (alternating magnetic field -AMF-) the SPIONs were able to generate a significant amount of heat. Hence, magnetic hyperthermia can be used as a remote trigger for release of drug cargos and SPIONs incorporated into the self-assembled dehydrodipeptide hydrogels.