Discovery of and Insights into DNA "Codes" for Tunable Morphologies of Metal Nanoparticles.
Discovery of and Insights into DNA "Codes" for Tunable Morphologies of Metal Nanoparticles.
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DOI：
10.1002/smll.201900975
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发表时间：
2019-05
期刊：
影响因子：
13.3
通讯作者：
Nitya Sai Reddy Satyavolu;K. Y. Loh;L. H. Tan;Yi Lu
中科院分区：
文献类型：
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作者：
Nitya Sai Reddy Satyavolu;K. Y. Loh;L. H. Tan;Yi Lu
遗传密码的发现和阐明不仅深刻地改变了生物学，而且改变了许多科学和工程领域。生命的基本组成部分包括四个简单的脱氧核糖核苷酸，但它们的组合作为遗传信息的载体，编码蛋白质，由于其独特的功能，可以执行许多生物功能。受自然界的启发，DNA分子的功能已被用作控制纳米材料形态的封端配体，并且这种控制是序列依赖性的，其转化为所得纳米颗粒的独特物理和化学性质。在此，提供了关于使用DNA作为用于控制金属纳米颗粒（例如金、银和Pd-Au纳米颗粒）的形态的工程化代码的概述。基于对DNA核碱基对各种金属的亲和力、核碱基组合的影响、DNA的功能修饰、DNA的二级结构以及所用种子的性质的理解，还总结了对DNA控制生长机制的基本见解。这些DNA编码的纳米材料的物理和化学性质也进行了审查，而DNA介导的纳米粒子合成的未来方向的前景提供。
The discovery and elucidation of genetic codes has profoundly changed not only biology but also many fields of science and engineering. The fundamental building blocks of life comprises of four simple deoxyribonucleotides and yet their combinations serve as the carrier of genetic information that encodes for proteins that can carry out many biological functions due to their unique functionalities. Inspired by nature, the functionalities of DNA molecules have been used as a capping ligand for controlling morphology of nanomaterials, and such a control is sequence dependent, which translates into distinct physical and chemical properties of resulting nanoparticles. Herein, an overview on the use of DNA as engineered codes for controlling the morphology of metal nanoparticles, such as gold, silver, and Pd-Au bimetallic nanoparticles is provided. Fundamental insights into rules governing DNA controlled growth mechanisms are also summarized, based on understanding of the affinity of the DNA nucleobases to various metals, the effect of combination of nucleobases, functional modification of DNA, the secondary structures of DNA, and the properties of the seed employed. The resulting physical and chemical properties of these DNA encoded nanomaterials are also reviewed, while perspectives into the future directions of DNA-mediated nanoparticle synthesis are provided.