The Expression and Survival Significance of Glucose Transporter-1 in Pancreatic Cancer: Meta-Analysis, Bioinformatics Analysis and Retrospective Study
The Expression and Survival Significance of Glucose Transporter-1 in Pancreatic Cancer: Meta-Analysis, Bioinformatics Analysis and Retrospective Study
复制标题
胰腺癌中葡萄糖转运蛋白1的表达及生存意义：Meta分析、生物信息学分析及回顾性研究
DOI：
10.1080/07357907.2021.1950755
复制
发表时间：
2021-08-02
影响因子：
2.4
通讯作者：
Li, Ji
中科院分区：
文献类型：
--
作者：
Du, Jiali;Gu, Jichun;Li, Ji
摘要为探讨GLUT-1在胰腺癌中的表达及其与预后的关系，采用Meta分析、基于GEO、Oncomine数据集和TCGA数据库的生物信息学分析和免疫组化方法，对88例胰腺导管腺癌（PDAC）患者肿瘤和正常组织中GLUT-1的表达进行研究。GLUT-1在胰腺癌中显著过表达，但不能作为预后的重要生物标志物。TNM分期和病理分级可作为胰腺癌患者预后不良的生物学指标。
Abstract To explore the expression profile and prognostic relevance of GLUT-1 in pancreatic cancer, a meta-analysis, bioinformatics analysis based on Gene Expression Omnibus (GEO), Oncomine dataset and The Cancer Genome Atlas (TCGA) database, and immunohistochemistry in tumor and normal tissue from 88 pancreatic ductal adenocarcinoma (PDAC) patients were performed. GLUT-1 was significantly overexpressed in pancreatic cancer but it could not be a significant biomarker for prognosis. TNM stage and pathological grade could be biomarker of poor prognosis of patients with pancreatic cancer.