Prato cheese containing Lactobacillus casei 01 fails to prevent dextran sodium sulphate-induced colitis
Prato cheese containing Lactobacillus casei 01 fails to prevent dextran sodium sulphate-induced colitis
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DOI：
10.1016/j.idairyj.2019.104551
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发表时间：
2019-12-01
影响因子：
3.1
通讯作者：
Azevedo, Vasco
中科院分区：
文献类型：
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作者：
Cordeiro, Barbara F.;Lemos, Luisa;Azevedo, Vasco
研究了含有干酪乳杆菌01的益生菌Prato干酪对葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎的预防作用。对于DSS体内模型，将小鼠分为6组。组1-3代表非炎症组，组4-6接受DSS(2%)溶液。实验1组和实验4组小鼠灌胃给予500亩L磷酸盐缓冲盐水(对照组)，实验2组和实验5组小鼠灌胃给予500亩常规普拉托奶酪(对照组)。最后，第3组和第6组小鼠灌胃给予500亩L含L干酪01(9.47logCFU mL(-1))的普拉托益生菌奶酪。服用益生菌Prato干酪的小组显示，由于摄入DSS溶液而导致的体重减轻。但益生菌干酪不能降低DSS诱导的结肠炎大鼠的炎症评分。总体而言，益生菌Prato干酪不能有效改善DSS诱导的结肠炎症状。(C)2019爱思唯尔有限公司。保留所有权利。
The role of experimental probiotic Prato cheese containing Lactobacillus casei 01 in the prevention of dextran sodium sulphate (DSS)-induced ulcerative colitis in mice was evaluated. For the DSS in vivo model, mice were divided into six groups. Groups 1-3 represented noninflamed groups and groups 4-6 received a DSS (2%) solution. Mice from groups 1 and 4 intragastrically received 500 mu L of phosphate-buffered saline (control groups), while mice from groups 2 and 5 intragastrically received 500 mu L of conventional Prato cheese (control groups). Finally, mice from group 3 and 6 intragastrically received 500 mu L of Prato probiotic cheese containing L casei 01 (9.47 log cfu mL(-1)). Groups treated with probiotic Prato cheese exhibited reduced weight loss caused by the consumption of DSS solution. However, the probiotic cheese failed to reduce the inflammation scores in DSS-induced colitis group. Overall, probiotic Prato cheese was not effective to ameliorate the symptoms of DSS-induced colitis. (C) 2019 Elsevier Ltd. All rights reserved.