Fitness, fatness and clustering of cardiovascular risk factors in children from Denmark, Estonia and Portugal: The European Youth Heart Study
Fitness, fatness and clustering of cardiovascular risk factors in children from Denmark, Estonia and Portugal: The European Youth Heart Study
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DOI：
10.1080/17477160801896366
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Andersen, Sigmund A.
中科院分区：
文献类型：
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作者：
Andersen, Lars B.;Sardinha, Luis B.;Andersen, Sigmund A.
背景儿童的超重程度有所增加，健康状况有所下降。这些变化可能对未来的健康构成威胁。许多研究测量了体重指数（BMI）的变化，但很少有研究评估低健身，超重和缺乏身体活动对心血管（CVD）风险因素的独立影响。方法.一项横断面多中心研究，包括来自丹麦、爱沙尼亚和葡萄牙的1769名儿童。主要结果是CVD危险因素的聚集。自变量为腰围、皮褶厚度、体力活动和心肺功能。结果腰围和皮褶都与聚集性CVD风险相关。当将收缩压、甘油三酯、胰岛素抵抗稳态评估模型（HOMA）评分、胆固醇：HDL和健康纳入评分时，上四分位数与最低四分位数相比，聚集性CVD风险的比值比为9.13（95%CI：5.78-14.43）和11.62（95%CI：7.11-18.99）。当健身从聚集的风险变量中删除时，肥胖的相关性减弱，进一步调整健身后，只有最高的四分位数的肥胖参数是显着的。健康状况与包括收缩压、甘油三酯、HONLI评分和胆固醇：HDL在内的聚集风险评分具有相同的关联强度，上四分位数的比值比为4.97（95%CI：3.20-7.73）。即使在调整健康和肥胖后，体力活动仍与聚集性风险相关，上四分位数的比值比为1.81（95%CI：1.18-2.76）。结论体力活动、健康状况、皮褶厚度和腰围均与聚集性心血管疾病风险独立相关。
Background. Levels of overweight have increased and fitness has decreased in children. Potentially, these changes may be a threat to future health. Numerous studies have measured changes in body mass index (BMI), but few have assessed the independent effects of low fitness, overweight and physical inactivity on cardiovascular (CVD) risk factors. Methods. A cross-sectional multi-center study including 1769 children from Denmark, Estonia and Portugal. The main outcome was clustering of CVD risk factors. Independent variables were waist circumference, skinfolds, physical activity and cardiorespiratory fitness. Results. Both waist circumference and skinfolds were associated with clustered CVD risk. Odds ratios for clustered CVD risk for the upper quartiles compared with the lowest quartile were 9.13 (95% CI: 5.78-14.43) and 11.62 (95% CI: 7.11-18.99) when systolic blood pressure, triglyceride, insulin resistance homeostasis assessment model (HOMA) score, cholesterol: HDL, and fitness were included in the score. When fitness was removed from the clustered risk variable, the association for fatness attenuated and after further adjustment for fitness, only the highest quartiles of the fatness parameters were significant. Fitness showed the same strength of association with the clustered risk score including systolic blood pressure, triglyceride, HONLI score, and cholesterol:HDL with odds ratio for the upper quartile of 4.97 (95% CI: 3.20-7.73). Physical activity was associated with clustered risk even after adjustment for fitness and fatness with an odds ratio for the upper quartile of 1.81 (95% CI: 1.18-2.76). Conclusion. Physical activity, fitness, skinfold and waist circumference were all independently associated with clustered CVD risk.