Invasion Types Are Associated With Poor Prognosis in Lung Squamous Carcinoma Patients.
Invasion Types Are Associated With Poor Prognosis in Lung Squamous Carcinoma Patients.
复制标题
侵袭类型与肺鳞癌患者的不良预后相关。
DOI：
10.1097/md.0000000000001634
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发表时间：
2015-10
期刊：
影响因子：
1.6
通讯作者：
Du J
中科院分区：
文献类型：
--
作者：
Zhao Y;Shen H;Qiu C;Zhang T;Hu P;Qu X;Liu Q;Du J
尽管肺腺癌组织学模式的预后意义正在被确定，但肺鳞癌中没有显着的预后指标被普遍接受为标准。本研究的目的是评估结合定义的侵袭类型的组织学特征，并区分可以反映预后的特征。我们检查了 132 名肺鳞癌患者的所有切片。根据世界卫生组织（WHO）分类对病例进行分类，评估肿瘤出芽、单细胞侵袭、大细胞侵袭、细胞学异型性程度、有丝分裂计数、芽数、瘤巢大小、纤维化和坏死情况。单因素分析显示，总生存率与年龄（P = 0.023）、淋巴结转移（P < 0.001）、远处器官转移（P < 0.001）、胸膜侵犯（P < 0.001）、肿瘤出芽（P = 0.003）、单细胞侵袭显着相关。 (P = 0.001)、有丝分裂计数(P < 0.001)和细胞学异型性程度(P = 0.009)。然而，2004 年 WHO 分类的亚型显示与结果无关（P = 0.209）。多因素分析显示，肺鳞癌的独立显着预后指标为肿瘤出芽（风险比[HR] = 0.466，P = 0.005）、单细胞侵袭（HR = 0.447，P = 0.003）、有丝分裂计数（HR = 0.502， P = 0.048）和细胞学异型性程度（HR = 0.479，P = 0.024）。具有侵袭类型的肺鳞癌与不良预后相关。
Although the prognostic significance of the histologic patterns in lung adenocarcinoma is being identified, no significant prognostic indicators in lung squamous carcinoma are accepted as a standard universally. The aim of this study was to evaluate the histologic characteristics incorporating the defined invasion types and distinguish the features that can reflect prognosis. We reviewed all slices of 132 patients with lung squamous carcinoma. The cases were classified according to the World Health Organization (WHO) classification and were evaluated for tumor budding, single cell invasion, large cell invasion, cytologic atypia degree, mitotic count, number of buds, tumor nest size, fibrosis, and necrosis. In univariate analysis, overall survival was associated significantly with age (P = 0.023), lymph nodes metastasis (P < 0.001), distant organ metastasis (P < 0.001), pleural invasion (P < 0.001), tumor budding (P = 0.003), single cell invasion (P = 0.001), mitotic count (P < 0.001), and the cytologic atypia degree (P = 0.009). However, the subtypes of 2004 WHO classification showed no association with outcome (P = 0.209). In multivariate analysis, the independent significant prognostic indicators of lung squamous carcinoma were tumor budding (hazard ratio [HR] = 0.466, P = 0.005), single cell invasion (HR = 0.447, P = 0.003), mitotic count (HR = 0.502, P = 0.048) and cytologic atypia degree (HR = 0.479, P = 0.024). Lung squamous carcinomas with the invasion types were associated with a poor prognosis.