Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet
Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet
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DOI：
10.1530/eje-09-0417
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发表时间：
2009-09-01
影响因子：
5.8
通讯作者：
Haluzik, Martin
中科院分区：
文献类型：
--
作者：
Dostalova, Ivana;Roubicek, Tomas;Haluzik, Martin
目的：巨噬细胞抑制性细胞因子-1（MIC-1）是一种新型的能量稳态调节因子。我们探讨了MIC-1水平的改变是否有助于肥胖和/或肥胖和2型糖尿病（T2 DM）患者的代谢紊乱设计：我们测定了17名肥胖非糖尿病妇女，14名肥胖妇女与T2 DM和23名健康瘦妇女的血清MIC-1水平及其在皮下和内脏脂肪组织中的mRNA表达。我们还探讨了MIC-1的关系。采用人体测量学和生化指标，研究了2周极低热量饮食（VLCD）对血清MIC-1水平的影响。结果：与对照组相比，肥胖组和T2 DM组血清MIC-1水平均显著升高（P < 0. 05）。T2 DM组血清MIC-1水平显著高于肥胖组。血清MIC-1与体重、体脂和血清甘油三酯水平呈正相关。血糖、糖化血红蛋白、C反应蛋白与血清高密度脂蛋白胆固醇呈负相关。脂肪mRNA MIC-1的表达在瘦型和肥胖型女性之间没有显着差异，但在两组中，皮下脂肪的MIC-1表达显着高于内脏脂肪。VLCD显著升高肥胖组血清MIC-1水平，但对T2 DM组无显著影响。肥胖患者中的水平因T2 DM的存在而进一步增加。我们认为，与癌症恶病质患者相比，MIC-1增加。肥胖患者和糖尿病患者中的水平不会引起体重减轻。
Objective: Macrophage inhibitory cytokine-1 (MIC-1) is a novel regulator of energy homeostasis. We explored whether alterations in MIC-1 levels contribute to metabolic disturbances in patients with obesity and/or obesity and type 2 diabetes mellitus (T2DM).Design: We measured serum MIC-1 levels and its mRNA expression in subcutaneous and visceral adipose tissue of 17 obese nondiabetic women, 14 obese women with T2DM and 23 healthy lean women. We also explored the relationship of MIC-1. with anthropometric and biochemical parameters and studied the influence of 2-week very low calorie diet (VLCD) on serum MIC-I levels.Methods: Serum MIC-1. levels were measured by ELISA and its mRNA expression was determined by RT-PCR.Results: Both obese and T2DM group had significantly elevated serum MIC-1 levels relative to controls. T2DM group had significantly higher serum MIC-1 levels relative to obese group. Serum MIC-1 positively correlated with body weight, body fat, and serum levels of triglycerides. glucose, HbAlc, and C-reactive protein and it was inversely related to serum high-density lipoprotein cholesterol. Fat mRNA MIC-1 expression did not significantly differ between lean and obese women but it was significantly higher in subcutaneous than in visceral fat in both groups. VLCD significantly increased serum MIC-1 levels in obese but not T2DM group.Conclusion: Elevated MIC-1. levels in patients with obesity are further increased by the presence of T2DM. We suggest that in contrast to patients with cancer cachexia, increased MIC-1. levels in obese patients and diabetic patients do not induce weight loss.