minet: A R/Bioconductor package for inferring large transcriptional networks using mutual information.

minet: A R/Bioconductor package for inferring large transcriptional networks using mutual information.
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DOI:
10.1186/1471-2105-9-461
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发表时间:
2008-10-29
期刊:
影响因子:
3
通讯作者:
Bontempi, Gianluca
Bontempi, Gianluca
中科院分区:
生物学4区
文献类型:
--
作者:
Meyer, Patrick E.;Lafitte, Frederic;Bontempi, Gianluca

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本文介绍了R/Bioconductor软件包嵌度(1.1.6版),该措施提供了一组功能来从数据集中推断相互信息网络。一旦用微阵列数据集喂食,该软件包将返回一个网络,其中nodes表示基因,边缘模型基因和边缘之间的统计依赖性量化了特定(例如转录)基因相互作用的统计证据。包装中的四个不同的熵估计量(经验,米勒 - 马杜,舒尔曼·格拉斯伯格和收缩)以及四种不同的推理方法,即相关性网络,即Aracne,CLR和MRNET。此外,该软件包还集成了精度评估工具,例如F得分,PR曲线和ROC曲线,以便将推论网络与参考网络进行比较。 软件包矿体提供了一系列用于从微阵列数据中推断转录网络的工具。它是从综合R档案网络(CRAN)以及生物导体网站上免费获得的。
This paper presents the R/Bioconductor package minet (version 1.1.6) which provides a set of functions to infer mutual information networks from a dataset. Once fed with a microarray dataset, the package returns a network where nodes denote genes, edges model statistical dependencies between genes and the weight of an edge quantifies the statistical evidence of a specific (e.g transcriptional) gene-to-gene interaction. Four different entropy estimators are made available in the package minet (empirical, Miller-Madow, Schurmann-Grassberger and shrink) as well as four different inference methods, namely relevance networks, ARACNE, CLR and MRNET. Also, the package integrates accuracy assessment tools, like F-scores, PR-curves and ROC-curves in order to compare the inferred network with a reference one. The package minet provides a series of tools for inferring transcriptional networks from microarray data. It is freely available from the Comprehensive R Archive Network (CRAN) as well as from the Bioconductor website.
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