Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
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DOI：
10.1136/ard.2010.140145
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发表时间：
2011-03-01
影响因子：
27.4
通讯作者：
Karin, Michael
中科院分区：
文献类型：
--
作者：
Grivennikov, Sergei I.;Karin, Michael
高达20%的所有癌症与慢性炎症相关，并且大多数（如果不是全部）实体瘤含有炎性浸润。免疫细胞对肿瘤的发生、生长和进展具有广泛的影响，其中许多作用是由促炎细胞因子介导的。在这些细胞因子中，肿瘤坏死因子（TNF）和白细胞介素6（IL-6）的促肿瘤发生功能已得到充分证实。TNF和IL-6作为肿瘤相关炎症和肿瘤发生的主要调节因子的作用使它们成为癌症辅助治疗的有吸引力的靶点
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all, solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour initiation, growth and progression and many of these effects are mediated by proinflammatory cytokines. Among these cytokines, the pro-tumourogenic function of tumour necrosis factor (TNF) and interleukin 6 (IL-6) is well established. The role of TNF and IL-6 as master regulators of tumour-associated inflammation and tumourigenesis makes them attractive targets for adjuvant treatment in cancer