Predictors of lithium treatment responsiveness in bipolar patients - A two-year prospective study
Predictors of lithium treatment responsiveness in bipolar patients - A two-year prospective study
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DOI：
10.1159/000026497
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发表时间：
1998-01-01
影响因子：
3.2
通讯作者：
Engelsmann, F
中科院分区：
文献类型：
--
作者：
Kusalic, M;Engelsmann, F
29名双相情感障碍患者在锂盐治疗开始前进行评估，以研究对治疗的长期反应的预后标准。评估包括临床和人口统计学数据以及治疗开始前和治疗开始后2-5天进行的实验室检查。测试包括钙和镁血清水平，甲状腺激素状态。随访2年。没有一个单一的变量预测锂治疗的反应，但临床和人口统计学变量的组合，用于判别函数分析，正确识别78.9%的反应者。多元回归分析预测46.2%的结果。最强的单变量预测因子是情绪质量、疾病持续时间和药物滥用。
Twenty-nine bipolar patients were assessed before the start of lithium therapy to study the prognostic criteria of long-term response to therapy. Assessment included clinical and demographic data and laboratory tests administered before and 2-5 days after initiation of therapy. The tests included calcium and magnesium serum levels, and thyroid hormonal status. Patients were followed up for 2 years. None of the single variables predicted the response to lithium therapy, but a combination of clinical and demographic variables, used in a discriminant function analysis, correctly identified 78.9% of responders. Multiple regression analysis predicted 46.2% of the outcome. The strongest univariate predictors were mood quality, illness duration, and substance abuse.