Platelet size: Measurement, physiology and vascular disease
Platelet size: Measurement, physiology and vascular disease
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DOI：
10.1097/00001721-199603000-00011
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发表时间：
1996-03-01
影响因子：
1.1
通讯作者：
Butterworth, RJ
中科院分区：
文献类型：
--
作者：
Bath, PMW;Butterworth, RJ
血小板体积是血小板功能和活化的标志物。通过使用柠檬酸钠作为抗凝剂的临床血液学分析仪，可以很容易地将其测量为平均血小板体积（MPV）。EDTA中的测量可能不可靠，因为MPV以时间依赖性方式显著增加。MPV与血小板功能和活化相关，无论是测量为聚集、血栓烷合成、β-血小板球蛋白释放、促凝血功能还是粘附分子表达。MPV在某些血管危险因素状态下增加，包括高胆固醇血症和糖尿病，但不包括原发性高血压。在急性心肌梗死、急性缺血性中风、先兆子痫和肾动脉狭窄中增加。重要的是，MPV升高预示着心肌梗死、冠状动脉血管成形术后再狭窄和先兆子痫的发生后预后不良。现在需要对MPV的流行病学进行研究，以确定血栓是否是发生血管疾病的危险因素。同样，巨核细胞内调节MPV的生理机制也需要阐明，MPV是否会成为一种常规要求的检测方法还有待观察，但首先需要改变方法。
Platelet volume is a marker of platelet function and activation. It is readily measured as mean platelet volume (MPV) by clinical haematology analysers using sodium citrate as the anticoagulant. Measurement in EDTA can be unreliable since MPV increases significantly in a time-dependent manner. MPV correlates with platelet function and activation, whether measured as aggregation, thromboxane synthesis, beta-thromboglobulin release, procoagulant function, or adhesion molecule expression. MPV is increased in certain vascular risk factor states, including hypercholesterolaemia and diabetes mellitus, but not essential hypertension. It is increased in acute myocardial infarction, acute ischaemic stroke, pre-eclampsia and renal artery stenosis. Importantly, an elevated MPV predicts a poor outcome following myocardial infarction, restenosis following coronary angioplasty, and the development of pre-eclampsia Research into the epidemiology of MPV is now required to determine whether thrombomegaly is a risk factor for developing vascular disease. Similarly, the physiological mechanisms which regulate MPV within the megakaryocyte need to be elucidated Whether MPV ever becomes a routinely requested test remains to be seen but changes in methodology will be required first.