Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer.
Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer.
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DOI：
10.1038/bjc.1995.193
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发表时间：
1995-05
影响因子：
8.8
通讯作者：
Bevilacqua, G
中科院分区：
文献类型：
--
作者：
Fontanini, G;Vignati, S;Bigini, D;Mussi, A;Lucchi, M;Angeletti, C A;Basolo, F;Bevilacqua, G
非小细胞肺癌（NSCLC）的预后与已确立的临床病理学参数密切相关，不幸的是，这些参数在此类癌症的预后评估中已变得不充分。由于p53和bcl-2基因异常常与多种上皮性恶性肿瘤有关，我们分别检测了91例和101例非小细胞肺癌中Bcl-2和p53蛋白的表达。然后将表达与肿瘤预后和生物学行为的既定指标进行比较。Bcl-2与临床病理学或生物学参数，如组织学，分级，肿瘤状态，淋巴结转移和增殖活性之间没有关系，通过增殖细胞核抗原表达和Ki-67免疫反应性评分进行评价。但在随访期间发生转移或死于转移性疾病的患者中，Bcl-2的平均表达显著降低（分别为P = 0.006和P = 0.01）。此外，Bcl-2蛋白表达的患者生存概率更高（P = 0.0002）。与此相反，p53蛋白积累中观察到的肿瘤转移淋巴结的参与（P = 0.02）或在随访期间发生转移的患者（P = 0.01），虽然没有发现p53表达和总生存率之间的相关性。Bcl-2与抑癌基因蛋白产物p53呈负相关（P = 0.01）。因此，高比例的NSCLC表达p53和Bcl-2蛋白，并且它们的表达可能具有预后重要性。
Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, we investigated the Bcl-2 and p53 protein expression in 91 and 101 cases of NSCLC respectively. The expression was then compared with established indicators of prognosis and biological behaviour of the tumours. No relationship was observed between Bcl-2 and either clinicopathological or biological parameters such as histology, grading, tumour status, nodal metastasis and proliferative activity evaluated by scoring proliferating cell nuclear antigen expression and Ki-67 immunoreactivity. However, the mean Bcl-2 expression was significantly lower in patients who developed metastasis during follow-up or died of metastatic disease (P = 0.006 and P = 0.01 respectively). Moreover, survival probability was higher in patients who expressed the Bcl-2 protein (P = 0.0002). In contrast with this, p53 protein accumulation was observed in tumours with metastatic nodal involvement (P = 0.02) or in patients who developed metastasis during follow-up (P = 0.01), although no correlation was found between p53 expression and overall survival. An inverse relationship was also found between Bcl-2 and the anti-oncogene protein product p53 (P = 0.01). Thus, a high proportion of NSCLCs express p53 and Bcl-2 proteins and their expression may have prognostic importance.