MicroRNA-150 A Novel Marker of Left Ventricular Remodeling After Acute Myocardial Infarction
MicroRNA-150 A Novel Marker of Left Ventricular Remodeling After Acute Myocardial Infarction
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DOI：
10.1161/circgenetics.113.000077
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发表时间：
2013-06-01
影响因子：
--
通讯作者：
Squire, Iain B.
中科院分区：
文献类型：
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作者：
Devaux, Yvan;Vausort, Melanie;Squire, Iain B.
背景--急性心肌梗死后左室(LV)重构与不良预后相关。MicroRNAs(MiRNAs)调节与左心室重构相关的几个基因的表达。我们的目的是确定与急性心肌梗死后左室重构相关的miRNAs。方法和结果：我们研究了90例首次ST段抬高的急性心肌梗死患者。以超声心动图为特征的60例患者出院前和6个月随访的衍生队列。以磁共振成像为特征的30名出院前患者和4个月随访的患者为验证队列。重构被定义为出院和随访之间左室舒张末期容量(Delta EDV>；0)的增加。用芯片和聚合酶链式反应检测循环中的miRNAs。使用基于系统的方法，我们确定了几个可能参与左室重构的miRNAs。在衍生队列中，其中一种miRNAs miR-150在有重塑的患者(Delta EDV>；0)中下调，而在没有重塑的患者(Delta EDV)中下调
Background- Left ventricular (LV) remodeling after acute myocardial infarction is associated with adverse prognosis. MicroRNAs (miRNAs) regulate the expression of several genes involved in LV remodeling. Our aim was to identify miRNAs associated with LV remodeling after acute myocardial infarction.Methods and Results- We studied 90 patients after first ST-segment-elevation acute myocardial infarction. A derivation cohort consisted of 60 patients characterized by echocardiography predischarge and at 6-month follow-up. Thirty patients characterized by magnetic resonance imaging predischarge and at 4-month follow-up were the validation cohort. Remodeling was defined as an increase in LV end-diastolic volume (Delta EDV>0) between discharge and follow-up. Circulating miRNAs were measured by microarrays and polymerase chain reaction. Using a systems-based approach, we identified several miRNAs potentially involved in LV remodeling. In the derivation cohort, one of these miRNAs, miR-150, was downregulated in patients with remodeling (Delta EDV>0) compared with patients without remodeling (Delta EDV