Electric blanket use and breast cancer in the Nurses' Health Study
Electric blanket use and breast cancer in the Nurses' Health Study
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DOI：
10.1093/aje/152.1.41
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发表时间：
2000-07-01
影响因子：
5
通讯作者：
Hunter, DJ
中科院分区：
文献类型：
--
作者：
Laden, F;Neas, LM;Hunter, DJ
电场和磁场（EMF）被认为会增加乳腺癌的风险，而电热毯是暴露于EMF的重要来源。作者在护士健康研究中调查了电热毯使用与浸润性乳腺癌之间的关系。在1992年的两年期调查表中，有87 497名妇女提供了连续三个时期的这方面信息。在一项前瞻性分析中，对301，775人-年（954例）进行了随访，直到1996年，在控制乳腺癌风险因素后，使用任何电热毯的相对风险均未升高（相对风险（RR）= 1.08，95%置信区间（CI）：0.95，1.24）。在年龄调整分析中，乳腺癌与诊断前至少16年使用电热毯和长期使用电热毯之间存在弱相关性，但在多变量模型中没有。在一项对1，318，683人-年随访（2，426例病例）的回顾性分析中，与疾病随访开始前使用相关的多变量相对风险为零（RR = 1.05，95% CI：0.95，1.16）。在按绝经分层并仅限于雌激素受体阳性乳腺癌的分析中获得了类似的结果。虽然这些估计值的95%置信区间并没有排除小风险，但总体而言，结果并不支持乳腺癌风险与电热毯电磁场暴露之间的关联。
Electric and magnetic fields (EMFs) have been hypothesized to increase the risk of breast cancer, and electric blankets represent an important source of exposure to EMFs. The authors examined the relation between electric blanket use and invasive breast cancer in the Nurses' Health Study. On the biennial questionnaire in 1992, 87,497 women provided information on this exposure during three consecutive time periods. In a prospective analysis with 301,775 person-years of follow-up through 1996 (954 cases), the relative risk for any electric blanket use was not elevated (relative risk (RR) = 1.08, 95% confidence interval (CI): 0.95, 1.24) after controlling for breast cancer risk factors. There was a weak association between breast cancer and electric blanket use at least 16 years before diagnosis and long-term use in age-adjusted analyses but not in multivariate models. In a retrospective analysis of 1,318,683 person-years of follow-up (2,426 cases), the multivariate relative risk associated with use before disease follow-up began was null (RR = 1.05, 95% CI: 0.95, 1.16). Similar results were obtained in analyses stratified by menopause and restricted to estrogen receptor-positive breast cancers. While 95% confidence intervals for these estimates did not exclude small risks, overall, results did not support an association between breast cancer risk and exposure to EMFs from electric blankets.