Detection of zonal renal ischemia with contrast-enhanced MR imaging with a macromolecular blood pool contrast agent.
Detection of zonal renal ischemia with contrast-enhanced MR imaging with a macromolecular blood pool contrast agent.
复制标题
使用大分子血池造影剂进行对比增强 MR 成像检测带状肾缺血。
DOI：
10.1002/jmri.1880020311
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Vexler,VS;Berthèzene,Y;Clément,O;Mühler,A;Rosenau,W;Moseley,ME;Brasch,RC
在大鼠肌红蛋白尿性急性肾衰竭（ARF）模型中研究了白蛋白-（二乙烯三胺五乙酸钆[DTPA]）35（一种大分子血池标记物）增强磁共振（MR）成像检测肾脏灌注局灶性变化的潜力。甘油注射后3小时，损伤肾脏的T1加权自旋回波增强后图像显示三个不同的区域：强烈增强的外皮质，低强度的内皮质和强烈增强的髓质。内皮层中明显的低强度带表明带状血容量减少，对应于显示内皮层中带状低灌注的已发表微球数据。实质区之间的对比度差异在至少30分钟内是显著的。在平扫图像上没有发现局灶性缺血改变。甘油注射后24小时，损伤肾脏的增强和非增强图像显示无区域分化。该ARF模型中的对比增强MR成像数据与病理数据和微球灌注结果相关性良好。MR成像对肾损伤缺血期的对比增强表征可提高ARF诊断的特异性，并可作为治疗干预的标志物。
The potential of magnetic resonance (MR) imaging enhanced with albumin‐(gadolinium diethylenetri‐aminepentaacetic acid [DTPA])35, a macromolecular blood pool marker, for detection of focal changes in renal perfusion was studied in a myoglobinuric acute renal failure (ARF) model in the rat. T1‐weighted spin‐echo postcontrast images of injured kidneys at 3 hours after glycerol injection showed three distinct zones: a strongly enhanced outer cortex, a low‐intensity inner cortex, and a strongly enhanced medulla. The distinct band of low intensity in the inner cortex indicated zonal decreased blood volume, corresponding to published microsphere data showing zonal low perfusion in the inner cortex. Contrast differences between parenchymal zones were significant for at least 30 minutes. No focal ischemic changes could be delineated on nonenhanced images. Enhanced and nonenhanced images of injured kidneys obtained at 24 hours after glycerol injection revealed no zonal differentiation. Contrast‐enhanced MR imaging data in this ARF model correlated well with pathologic data and microsphere perfusion results. Contrast‐enhanced characterization of the ischemic phase of renal injury with MR imaging may improve specificity for the diagnosis of ARF and may serve as a marker for therapeutic intervention.