Expression of the immunoglobulin heavy-chain variable gene repertoire.
Expression of the immunoglobulin heavy-chain variable gene repertoire.
复制标题
免疫球蛋白重链可变基因库的表达。
DOI：
10.1007/978-3-642-71851-9_6
复制
发表时间：
1987
影响因子：
--
通讯作者：
Alt,FW
中科院分区：
文献类型：
--
作者：
Malynn,BA;Berman,JE;Yancopoulos,GD;Bona,CA;Alt,FW
免疫学的一个主要挑战是阐明决定表达抗体库的细胞和分子机制。已经积累了大量关于小鼠抗体基因组织和多样性的知识。然而，控制这些基因使用的潜在过程仍然存在疑问。了解免疫球蛋白可变(V)基因重排的调节机制以及不同V基因家族在发育中的B细胞群体中的相对表达，可能对于理解正常和疾病状态下抗体谱的生成至关重要。目前对人类VH基因组织和多样性的研究将最终允许将获得的关于小鼠基因谱系的信息扩展到人类VH基因使用的研究。
A major challenge in immunology is the elucidation of the cellular and molecular mechanisms which determine the expressed antibody repertoire. A large body of knowledge concerning murine antibody gene organization and diversity has been accumulated. However, the underlying processes governing usage of these genes remains in question. Knowledge of the mechanisms which regulate immunoglobulin variable (V) gene rearrangement and the relative expression of the variousVgene families in developing B–cell populations may be crucial to an understanding of generation of the antibody repertoire in normal as well as disease states. Current investigation of humanVHgene organization and diversity will evwntually allow extension of information gained about the murine repertoire to studies ofVHgene usage in humans.