A New Biomechanical Deformation Response Parameter: Change in Central Corneal Thickness During Air Puff Induced Corneal Deformation.
A New Biomechanical Deformation Response Parameter: Change in Central Corneal Thickness During Air Puff Induced Corneal Deformation.
复制标题
一种新的生物力学变形响应参数：吹气引起角膜变形期间中央角膜厚度的变化。
DOI：
10.1080/02713683.2024.2338228
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发表时间：
2024
影响因子：
2
通讯作者：
Roberts,CynthiaJ
中科院分区：
文献类型：
--
作者：
Okon,MonicaD;Ma,Yanhui;Nguyen-Rudy,BAudrey;Roberts,CynthiaJ
目的探讨充气变形过程中角膜中央厚度变化百分比（%ΔCCT）作为角膜生物力学响应的指标。方法选取40例供体的40只活体眼，在实验控制眼压为10、20、30和40 mmHg的条件下，采用CorVis ST成像，然后进行单轴条形测试，计算拉伸模量。CorVis ST研究软件跟踪角膜前后边缘，确定动态角膜反应（DCR）参数。如果存在图像质量或后向跟踪问题，则将眼睛排除在外。使用自定义算法计算变形期间的CCT，使用光线追踪方法校正每张图像中的Scheimpflug和光学畸变。对形状相关DCR参数与%ΔCCT进行相关分析和逐步回归分析。采用混合模型分析来检验IOP的影响以及逐步回归对%ΔCCT的最强显著预测因子。显著性阈值设top< 0.05。结果最终分析30只眼，各IOP水平CCT从预变形状态到最高凹度状态均显著升高（p< 0.001）。IOP和多形态dcr与%ΔCCT显著相关（p< 0.0001）。%ΔCCT的最强预测因子是积分逆半径（IIR） （p< 0.0001；偏R2= 0.4772），没有其他参数的偏R2值大于0.04。混合模型分析显示IIR是唯一预测因子（p= 0.0098）， IOP作为单一预测因子不再显著。然而，IIR与IOP的相互作用（p= 0.0023）对%ΔCCT有显著影响。结论CCT百分比变化受角膜硬度的影响，与IIR有显著关系。%ΔCCT可能是确定角膜变形反应与角膜疾病差异的潜在生物标志物。
PurposeTo investigate the percent change in central corneal thickness (%ΔCCT) during air-puff-induced deformation as an indicator of corneal biomechanical response.MethodsFortyex vivohuman eyes from forty donors were imaged using the CorVis ST at experimentally controlled intraocular pressure (IOP) of 10, 20, 30, and 40 mmHg, followed by uniaxial strip testing to calculate tensile modulus. The CorVis ST research software tracked the anterior and posterior cornea edges and determined the dynamic corneal response (DCR) parameters. Eyes were excluded if image quality or posterior tracking issues were present. Custom algorithms were used to calculate CCT during deformation using a ray-tracing method to correct for Scheimpflug and optical distortion within each image. Correlation and stepwise regression analyses between the shape-related DCR parameters and %ΔCCT were conducted. A mixed model analysis was performed to test the effect of IOP and the strongest significant predictors of the stepwise regression on %ΔCCT. The significance threshold was set top< 0.05.ResultsThirty eyes were ultimately analyzed and CCT increased significantly from the pre-deformation state to the highest concavity state at each IOP level (p< 0.001). IOP and multiple shape DCRs were found to be significantly related to %ΔCCT (p< 0.0001). The strongest predictor of %ΔCCT was integrated inverse radius (IIR) (p< 0.0001; partial R2= 0.4772) with no other parameter having a partial R2value greater than 0.04. The mixed model analysis showed that IIR was the sole predictor (p= 0.0098) and IOP was no longer significant as a single predictor. However, the interaction of IIR with IOP (p= 0.0023) had a significant effect on %ΔCCT.ConclusionPercent change in CCT is influenced by corneal stiffness as indicated by the significant relationship with IIR. The %ΔCCT may be a potential biomarker for determining differences in corneal deformation response with corneal diseases.
影响因子：
2.8
作者：
Roberts CJ;Dupps WJ Jr
通讯作者：
Dupps WJ Jr
影响因子：
4.4
作者：
Winkler, Moritz;Chai, Dongyul;Jester, James V.
通讯作者：
Jester, James V.
影响因子：
1.9
作者：
Lopes BT;Roberts CJ;Elsheikh A;Vinciguerra R;Vinciguerra P;Reisdorf S;Berger S;Koprowski R;Ambrósio R Jr
通讯作者：
Ambrósio R Jr