ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN FRAGMENTS IN SHR
ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN FRAGMENTS IN SHR
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DOI：
10.1271/bbb.59.1398
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发表时间：
1995-08-01
影响因子：
1.6
通讯作者：
OSAJIMA, Y
中科院分区：
文献类型：
--
作者：
MATSUFUJI, H;MATSUI, T;OSAJIMA, Y
血管紧张素Ⅲ（ANG Ⅲ）与自发性高血压大鼠（SHR）血浆孵育后，发现具有ACE抑制活性的四种血管紧张素（Val-Tyr）片段和具有ACE抑制活性的血管紧张素Ⅲ（ANG Ⅲ）片段均能显著降低SHR的舒张压。（ANG（3-4））（IC 50 = 26.0 μ M）、Ile-His-Pro-Phe（ANG（5-8））（11.6 μ M）、Tyr-ne-His-Pro-Phe（ANG（4-8））（457.5 μ M）和Val-Tyr-Ile-His-Pro-Phe（ANG（3-8））（6.55 μ M）。比较SHR和正常Wistar大鼠血浆中ANG Ⅱ的代谢行为，发现Wistar大鼠血浆中ANG Ⅱ的初始降解速率（3.07nmol/ml/min）比SHR高2倍左右（1.75nmol/ml/min）。
When angiotensin fragments, Val-Tyr and Angiotensin III (ANG III), with potent ACE inhibitory activity were intravenously administered to spontaneously hypertensive Fat (SHR), a significant reduction of diastolic blood pressure was observed, After incubation of ANG III with SHR plasma, four fragments with ACE inhibitory activity, Val-Tyr (ANG (3-4)) (IC50 = 26.0 mu M), Ile-His-Pro-Phe (ANG (5-8)) (11.6 mu M), Tyr-ne-His-Pro-Phe (ANG (4-8)) (457.5 mu M), and Val-Tyr-Ile-His-Pro-Phe (ANG (3-8)) (6.55 mu M), were confirmed to generate in SHR plasma. Compared the metabolic behavior of ANG II in SHR plasma with that in normotensive Wistar plasma, the initial degradation rate (3.07 nmol/ml/min) in Wistar plasma was about 2-fold higher than that in the SHR one (1.75 nmol/ml/min).