The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress
The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress
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DOI：
10.1042/bst0360930
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发表时间：
2008-10-01
影响因子：
3.9
通讯作者：
Maechler, Pierre
中科院分区：
文献类型：
--
作者：
Li, Ning;Frigerio, Francesca;Maechler, Pierre
胰腺β细胞对于维持葡萄糖稳态是必不可少的，并且这些胰岛素分泌细胞的功能障碍导致糖尿病的发展。在从肥胖到2型糖尿病的过程中，目前设想了几种机制。其中，脂质和氧化应激被认为是β细胞的毒性候选者。脂肪酸和ROS（活性氧）之间的细胞联系基本上是胰岛素分泌控制的关键细胞器。线粒体是ROS的主要来源，也是氧化攻击的主要靶点。本综述介绍了目前的知识与氧化应激的背景下，在β细胞线粒体功能的脂毒性。
Pancreatic beta-cells are essential for the maintenance of glucose homoeostasis, and dysfunction of these insulin-secreting cells results in the development of diabetes. in the course of events leading from obesity to Type 2 diabetes, several mechanisms are currently envisaged. Among them, lipids and oxidative stress are considered as toxic candidates for the beta-cell. The cellular link between fatty acids and ROS (reactive oxygen species) is essentially the mitochondrion, a key organelle for the control of insulin secretion. Mitochondria are the main source of ROS and are also the primary target of oxidative attacks. The present review presents the current knowledge of lipotoxicity related to oxidative stress in the context of mitochondrial function in the beta-cell.