Neuroleptic-induced oral movements in rats: methodological issues.
Neuroleptic-induced oral movements in rats: methodological issues.
复制标题
抗精神病药引起的大鼠口腔运动：方法学问题。
DOI：
10.1016/0024-3205(87)90715-6
复制
发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Ellison,GD
中科院分区：
文献类型：
--
作者：
Levy,AD;See,RE;Levin,ED;Ellison,GD
In three separate experiments groups of rats were chronically administered neuroleptics in a variety of ways (chronic injections, subcutaneous implants, and decanoate injections) and examined for oral movements (OMs) in two different tests: in an open cage using a human observer, or in a plexiglas tube enclosure, where OMs were monitored both by a human observer and computerized video analysis system. These two testing methods showed different effects of neuroleptic administration. In the open cage, OMs tended to be enhanced during chronic neuroleptic exposure and to rapidly subside upon drug withdrawal. The enhanced OMs were especially present just after drug injections, when activity levels were low. In the observation tube environment, however, OMs tended to be low soon after drug treatments, and elevated upon withdrawal. Thus, the type of behavioral test used determines how neuroleptic-induced increases in oral activity should be interpreted.
