Radical scavenging by flavonoid antioxidants.
Radical scavenging by flavonoid antioxidants.
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DOI：
10.3109/10715768709065294
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发表时间：
1987-01-01
期刊：
影响因子：
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通讯作者：
Saran, M
中科院分区：
文献类型：
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作者：
Bors, W;Saran, M
15种结构不同的黄酮类化合物的芳氧基自由基由叠氮自由基（N3）的攻击产生。对溶于pH 11.5水溶液的母体化合物的影响。生成速率常数都非常高（2.4-8.8 x 10（9）dm 3 mol-1 s-1），而衰变速率则有很大差异，范围从10（5）到10（8）dm 3 mol-1 s-1。在大多数情况下，瞬态aroxyl自由基的光谱特性与母体化合物的结构特征有关，根据光谱相似性，它们可以分为三个不同的组（只有两个例外）。虽然这些数据并不能最终证明类黄酮的生物学功能可能是清除自由基，但一些芳氧基自由基的形成速率常数和相对稳定性非常高，这支持了这一假设。
Aroxyl radicals of fifteen structurally distinct flavonoids were generated by attack of azide radicals (N3.) on the parent compounds dissolved in aqueous solution at pH 11.5. Generation rate constants were all found to be very high (2.4-8.8 x 10(9) dm3mol-1 s-1), whereas the decay rates differed considerably, ranging from 10(5) to 10(8) dm3mol-1 s-1. In most cases the spectral characteristics of the transient aroxyl radicals relate to structural features of the parent compounds and according to spectral similarities they can be classed in three distinct groups (with only two exceptions). Although the data do not conclusively prove that the biological function of flavonoids might be the scavenging of radicals, the very high rate constants of formation and the relative stability of some of the aroxyl radicals, are in support of such a hypothesis.