Barrier stabilizing mediators in regulation of microvascular endothelial permeability.
Barrier stabilizing mediators in regulation of microvascular endothelial permeability.
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DOI：
10.3760/cma.j.issn.1008-1275.2012.02.008
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Huang QB
中科院分区：
文献类型：
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作者：
Huang QB
微血管通透性增加是创伤和烧伤发病机制中最重要的病理事件之一。大量的液体从血管间隙渗漏，导致血浆丢失，有效循环血容量减少，导致严重的组织水肿、低血压甚至休克，尤其是严重烧伤。长期以来，由于对血管高通透性反应的机制缺乏全面和深入的了解，液体复苏一直是维持患者血容量的唯一有效方法。近年来出现了一种新的概念，即一些所谓的屏障稳定介质在防止血管通透性增加方面起着积极的作用。这些介质可能是对促炎介质的反应而释放的，并有助于恢复内皮屏障的功能。其中一些稳定介质即使在静止状态下也很重要，因为它们在低水平保持基础血管的通透性。这篇综述介绍了其中的一些介质，并揭示了它们在内皮屏障增强过程中的潜在信号机制。
Increase of microvascular permeability is one of the most important pathological events in the pathogenesis of trauma and burn injury. Massive leakage of fluid from vascular space leads to lose of blood plasma and decrease of effective circulatory blood volume, resulting in formation of severe tissue edema, hypotension or even shock, especially in severe burn injury. Fluid resuscitation has been the only valid approach to sustain patient’s blood volume for a long time, due to the lack of overall and profound understanding of the mechanisms of vascular hyperpermeability response. There is an emerging concept in recent years that some so-called barrier stabilizing mediators play a positive role in preventing the increase of vascular permeability. These mediators may be released in response to proinflammatory mediators and serve to restore endothelial barrier function. Some of these stabilizing mediators are important even in quiescent state because they preserve basal vascular permeability at low levels. This review introduces some of these mediators and reveals their underlying signaling mechanisms during endothelial barrier enhancing process.