RELATIONSHIP OF ISLET FUNCTION TO INSULIN ACTION IN HUMAN OBESITY
RELATIONSHIP OF ISLET FUNCTION TO INSULIN ACTION IN HUMAN OBESITY
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DOI：
10.1210/jcem-65-1-59
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发表时间：
1987-07-01
影响因子：
5.8
通讯作者：
PORTE, D
中科院分区：
文献类型：
--
作者：
BEARD, JC;WARD, WK;PORTE, D
为了分析肥胖的B细胞机制，我们测量了从瘦到明显肥胖的非糖尿病受试者中葡萄糖水平和对异丙肾上腺素或精氨酸的急性胰岛素反应（AIR）之间的关系（增强斜率）。在基础葡萄糖水平下，肥胖男性（n = 9）对异丙肾上腺素的AIR高于瘦人（n = 11）[52 . ±. 9（SEM）vs. 32 . ±-. 5 μ U/mL; P < 0.05]，并且该差异随着环境葡萄糖水平的升高而增加（在230 mg/dL; 263 ± 0.5 μ U/mL）。22对140 +-。21 μ U/mL; P < 0.0008）。AIR对异丙肾上腺素的葡萄糖增强作用的斜率与超重呈正相关（r = 0.72; P < 0.001）。在其他男性和女性中使用精氨酸作为促分泌素时，也发现了类似的结果;增强斜率与男性和女性的超重呈正相关（均P < 0.005），尽管超重对斜率的影响在男性中高出51%（P < 0.03）。对女性进行了胰岛素敏感性的独立测量（Bergman S1）。增强斜率与S1呈负相关（P < 0.0001），表明肥胖对胰岛素分泌的影响与胰岛素抵抗有关。这些结果表征了导致肥胖症高胰岛素血症的一种机制，并强调了在评估胰岛功能时考虑普遍的胰岛素敏感性的重要性。
To analyze B-cell mechanisms in obesity, we measured the relationship (slope of potentiation) between glucose levels and acute insulin responses (AIR) to isoproterenol or arginine in nondiabetic subjects ranging from lean to markedly obese. Obese men (n = 9) had higher AIRs to isoproterenol than lean men (n = 11) at basal glucose levels [52 .+-. 9 (SEM) vs. 32 .+-. 5 .mu.U/mL; P < 0.05], and the difference increased as the ambient glucose level was raised (at 230 mg/dL; 263 .+-. 22 vs. 140 .+-. 21 .mu.U/mL; P < 0.0008). The individuals'' slopes of glucose potentiation of AIR to isoproterenol were positively correlated with their excess weight (r = 0.72; P < 0.001). Similar results were found when arginine was used as the secretagogue in other men and in women; the slope of potentiation was positively correlated with excess weight in both men and women (both P < 0.005), although the effect of excess weight on slope was 51% greater among men (P < 0.03). An independent measurement of insulin sensitivity (the Bergman S1) was made in the women. The potentiation slope was inversely correlated with S1 (P < 0.0001), indicating that the effect of obesity on insulin secretion is correlated with insulin resistance. These results characterize one mechanism contributing to the hyperinsulinemia of obesity and highlight the importance of considering the prevailing insulin sensitivity when assessing islet function.