Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.
Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.
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DOI：
10.1002/mnfr.201300481
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发表时间：
2014-05
影响因子：
5.2
通讯作者：
O. Torres;J. Matute;J. G. Gelineau-van Waes;J. Maddox;S. Gregory;A. Ashley-Koch;J. L. Showker;N. Zitomer;K. Voss;R. Riley
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文献类型：
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作者：
O. Torres;J. Matute;J. G. Gelineau-van Waes;J. Maddox;S. Gregory;A. Ashley-Koch;J. L. Showker;N. Zitomer;K. Voss;R. Riley
当玉米为主食时，伏马菌素（FB）的摄入量可能很高。我们测定了(i)危地马拉高暴露和低暴露社区中食用玉米的妇女尿中FB (UFB), （ii）玉米中的FB水平，（iii） UFB与FB摄入量之间的关系，以及（iv） UFB1、UFB2和UFB3的相对排泄量。方法与结果对3个科室1年的尿液和玉米进行分析。通过访谈问卷估计玉米消费量。100%的玉米样品检测到伏马菌素B1、B2和B3 （FB1、FB2和FB3）。胡蒂亚帕玉米和尿液中的FB1含量明显高于奇玛特南戈和埃斯昆特拉。FB摄入量与UFB1呈剂量依赖关系，但与玉米相比，UFB1的含量远高于UFB2或UFB3。结论胡蒂亚帕农业生态条件有利于青稞的生产。UFB1反映了估计的FB摄入量。与未检测到UFB1的妇女相比，0.1 ng/mL的UFB1导致FB摄入量超过2 μg/kg体重/天的风险呈剂量依赖性增加。当UFB1浓度为0.5 ng/mL时，50%以上的小鼠超过2 μg/kg b.w./day。很少检测到UFB2和UFB3，证实了FB1被更好地吸收或优先通过尿液排出。
SCOPE Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1 , UFB2 , and UFB3 . METHODS AND RESULTS Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1 , B2 , and B3 (FB1 , FB2 and FB3 ), were detected in 100% of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. CONCLUSION In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1 . More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.