Osteoarthritis year in review 2017: genetics and epigenetics.
Osteoarthritis year in review 2017: genetics and epigenetics.
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DOI：
10.1016/j.joca.2017.09.009
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发表时间：
2018-03
影响因子：
7
通讯作者：
Smagul A
中科院分区：
文献类型：
--
作者：
Peffers MJ;Balaskas P;Smagul A
该综述旨在识别2017年4月至2018年1月期间发表的骨关节炎（OA）遗传学和表观遗传学文献的亮点。使用关键词“骨关节炎”和以下各项进行Pubmed文献检索：“基因组学”、“遗传学”、"表观基因组学“、”表观遗传学“、”组蛋白“、”非编码RNA“、”miRNA“、”lncRNA"、"DNA甲基化“、" DNA羟甲基化"、”DNMT“和”TET“。出版日期仅限于2017年4月1日至2018年1月15日。将结果与限于2016年4月1日至2017年1月15日的相同检索词进行比较。几乎所有的搜索词组合都显示，与去年相比，今年发表的论文有所减少，表观遗传和miRNA/lncRNA研究保持稳定。尽管如此，今年取得了许多进展，包括手部OA的第二次大型GWAS研究，髋关节和膝关节OA一致性的新双胞胎研究，GDF 5进化的广泛研究，Dnmt 3a对OA的贡献的分析，OA非人灵长类动物模型中DNA甲基化的描述，以及人类OA样本中DNA甲基化，mRNA和蛋白质表达的综合，多组学分析，还有其他的还发表了各种微RNA和一些环状RNA的研究，强调了非编码RNA在OA发病机制和潜在治疗中的重要性。虽然出版物在去年略有下降，遗传学和表观遗传学仍然是OA的实质性研究的主题，并在该领域继续取得相当大的进展。
This review was designed to identify highlights of the osteoarthritis (OA) genetics and epigenetics literature published between April 2017 and January 2018. A Pubmed literature search was conducted using the keywords ‘osteoarthritis’ and each of the following: ‘genomic’, ‘genetic’, ‘epigenomic’, ‘epigenetic’, ‘histone’, ‘noncoding RNA’, ‘miRNA’, ‘lncRNA’, ‘DNA methylation’, ‘DNA hydroxymethylation’, ‘DNMT’, and ‘TET’. The dates of publication were restricted to 4/1/2017 - 1/15/2018. Results were compared to the same search terms limited to 4/1/2016-1/15/2017. Virtually all search term combinations demonstrated a decrease in papers published this year compared to last, with epigenetic and miRNA/lncRNA research being stable. Despite this, numerous advances were made this year, including the second large GWAS study of hand OA, a new twin study of hip and knee OA concordance, an extensive study of GDF5 evolution, analyses of the contribution of Dnmt3a to OA, a description of DNA methylation in a nonhuman primate model of OA, and an integrated, multi-omics analysis of DNA methylation, mRNA, and protein expression in human OA samples, among others. A variety of micro- and a few circular-RNA studies were also published, highlighting the importance of noncoding RNA in both the pathogenesis and potential treatment of OA. Although publications have decreased slightly in the last year, genetics and epigenetics continue to be a topic of substantial research in OA, and considerable progress continues to be made in the field.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
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通讯作者：
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影响因子：
12.3
作者：
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通讯作者：
Horvath S
影响因子：
7
作者：
D'Adamo, S.;Cetrullo, S.;Flamigni, F.
通讯作者：
Flamigni, F.
影响因子：
1.6
作者：
Gu R;Liu N;Luo S;Huang W;Zha Z;Yang J
通讯作者：
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