Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment.
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment.
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DOI：
10.3389/fmicb.2021.744167
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发表时间：
2021
影响因子：
5.2
通讯作者：
Karakousis PC
中科院分区：
文献类型：
--
作者：
Danchik C;Wang S;Karakousis PC
严格反应在细菌物种中是保守的，并且是涉及细菌存活和毒力以及分枝杆菌中抗生素耐受性诱导的关键途径。它是由alarmone（p）ppGpp和调节分子无机多磷酸盐介导的，以响应营养饥饿等应激条件。针对严格应答的各种组分的靶向治疗的努力已经显示出在调节分枝杆菌毒力和抗生素耐受性方面的前景。在这篇综述中，我们总结了目前对严格反应及其在分枝杆菌毒力和耐受性中的作用的理解，包括靶向该途径可能具有治疗益处的证据。
The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria. It is mediated by the alarmone (p)ppGpp and the regulatory molecule inorganic polyphosphate in response to stress conditions such as nutrient starvation. Efforts to pharmacologically target various components of the stringent response have shown promise in modulating mycobacterial virulence and antibiotic tolerance. In this review, we summarize the current understanding of the stringent response and its role in virulence and tolerance in Mycobacteria, including evidence that targeting this pathway could have therapeutic benefit.