Mild ovarian stimulation
Mild ovarian stimulation
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DOI：
10.1007/s10815-007-9179-9
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发表时间：
2007-12-01
影响因子：
3.1
通讯作者：
Check, Jerome H.
中科院分区：
文献类型：
--
作者：
Check, Jerome H.
目的探讨单纯温和促排卵方案在体外受精中的作用。方法采用3种不同的轻度刺激方案：完全不使用外源性促卵泡激素（FSH）的自然刺激方案、自然刺激加小剂量FSH促进卵泡成熟方案和月经周期第3-5天小剂量FSH（75- 150 IU）的轻度刺激方案。炔雌醇有时被用来降低高3天血清FSH。结果良好的妊娠率和种植率，即使在那些妇女血清FSH升高，只能产生一个follows.Conclusions温和的卵巢刺激似乎更可取的高剂量FSH方案的妇女血清FSH升高3天的基础上，以前的不良报道妊娠率与后者的协议。在卵子储备正常的妇女中，高剂量方案的妊娠率相当，风险和成本低得多。
Purpose To evaluate the efficacy of using only mild ovarian stimulation protocols for in vitro fertilization. Both groups with decreased and normal ovarian reserve were evaluated.Methods Three different mild stimulation protocols were evaluated: natural with no exogenous follicle stimulation hormone (FSH) drugs at all, natural with a boost of low dose FSH to complete follicular maturation, and minimal stimulation with low dose (75-150IU) FSH from day 3-5 of the menstrual cycle. Ethinyl estradiol was sometimes used to lower high day 3 serum FSH.Results Good pregnancy and implantation rates were found even in those women with elevated serum FSH that could only generate one follicle.Conclusions Mild ovarian stimulation seems preferable to high dose FSH regimens in women with elevated day 3 serum FSH based on previous poor reported pregnancy rates with the latter protocols. Comparable pregnancy rates to high dose regimen were seen in women with normal egg reserve at much lower risk and cost.