Frequency of cervical intraepithelial neoplasia following large loop excision of the transformation zone
Frequency of cervical intraepithelial neoplasia following large loop excision of the transformation zone
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DOI：
10.1136/jcp.51.5.375
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发表时间：
1998-05-01
影响因子：
3.4
通讯作者：
Dixon, R
中科院分区：
文献类型：
--
作者：
Hulman, G;Pickles, CJ;Dixon, R
目的：根据宫颈大环切除术(LLETZ)后宫颈上皮内瘤变(CIN)的发生情况，根据宫颈上皮内瘤变(CIN)的分级和切除程度，确定宫颈上皮内瘤变(CIN)的发生率。方法对669例宫颈大环切除CIN 1、2、3的患者进行回顾性研究。随访期1.5~3.5年。结果CIN的持续/复发频率随CIN分级的增加而增加：CIN 1、CIN 2和CIN 3患者中有6.7%、13.4%和21.7%发生持续或复发。CIN完全切除组(8.4%)显著低于不完全切除组(31.3%)(p<；0.0001)或可疑组(27.8%)(p<；0.0001)。结论：CIN切除不完全或不明确的患者应仔细随访，最好在镜下进行。完全切除的高级别CIN患者需要仔细的宫颈细胞学监测。
Aim-To determine the frequency of cervical intraepithelial neoplasia (CIN) following large loop excision of the transformation zone of the cervix (LLETZ) according to grade and completeness of excision of GIN.Methods-A retrospective study of 669 patients who had LLETZ biopsies showing CIN 1, 2, or 3. The patients were subdivided according to the grade and completeness of excision of GIN. The follow up period was 1.5 to 3.5 years. Risk of persistent/recurrent CIN was assessed by the frequency of histological diagnosis of CIN during the follow up period.Results-Frequency of persistent/recurrent CIN increased with the grade of CIN reported: 6.7% of patients with CIN 1, 13.4% with CIN 2, and 21.7% with CIN 3 developed persistence or recurrence. The frequency of CIN persistence/recurrence was significantly lower where LLETZ showed complete excision of CIN (8.4%) than where it was incomplete (31.3%) (p < 0.0001) or equivocal (27.8%) (p < 0.0001).Conclusions-Patients with incomplete or equivocal excision of all grades of CIN merit careful, preferably colposcopic, follow up. Patients with completely excised high grade CIN require careful cervical cytologic surveillance.