Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents
Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents
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DOI：
10.1016/j.neulet.2005.10.097
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发表时间：
2006-03-06
影响因子：
2.5
通讯作者：
Offen, D
中科院分区：
文献类型：
--
作者：
Hellmann, MA;Panet, H;Offen, D
帕金森病的特征是黑质中多巴胺能神经元的丧失。用干细胞替代这些神经元的尝试已被证明是不确定的。骨髓间充质干细胞（MSC）是多能的，可分化为多种细胞，包括神经元样细胞。我们使用6-羟基多巴胺（6-OHDA）帕金森病动物模型来评估移植MSC的迁移和分化。我们发现在啮齿动物中，移植的MSC在6-OHDA诱导的受损半球中比未受损侧存活得更好。此外，对侧移植的MSC通过胼胝体迁移到6-OHDA损伤半球的纹状体、丘脑核和黑质。总之，我们证明了6-OHDA诱导的损伤增加了移植MSC的活力，并从对侧半球吸引这些细胞。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. Attempted replacement of these neurons by stem cells has proved inconclusive. Bone marrow mesenchymal stem cells (MSC) are multipotent, differentiating into a variety of cells, including neuron-like cells. We used the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease to assess migration and differentiation of transplanted MSC. We found in rodents that transplanted MSC survive better in the 6-OHDA-induced damaged hemisphere compared to the unlesioned side. Moreover, contralaterally engrafted MSC migrated through the corpus callosum to populate the striatum, thalamic nuclei and substantia nigra of the 6-OHDA-lesioned hemisphere. In conclusion, we demonstrate that 6-OHDA-induced damage increases the viability of transplanted MSC and attracts these cells from the opposite hemisphere. (c) 2005 Elsevier Ireland Ltd. All rights reserved.