LEFT-VENTRICULAR EFFECTS ON RIGHT VENTRICULAR DEVELOPED PRESSURE
LEFT-VENTRICULAR EFFECTS ON RIGHT VENTRICULAR DEVELOPED PRESSURE
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DOI：
10.1152/jappl.1976.41.6.925
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发表时间：
1976-01-01
影响因子：
3.3
通讯作者：
MEIER, GD
中科院分区：
文献类型：
--
作者：
SANTAMORE, WP;LYNCH, PR;MEIER, GD
The possibility that left ventricular (LV) performance affects right ventricular (RV) function through the myocardium was examined by using isolated, flow-perfused, paced rabbit hearts beating isovolumically. Reducing LV volume from its optimal volume to 0 caused a 5.7% decrease (N [degrees of freedom] = 10, P < 0.001) in right ventricular developed pressure (RVDP). Ligating the anterior ventricular branches of the left coronary artery which in the rabbit supply the LV free wall resulted in an additional 9.3% decrease in RVDP (N = 5, P = 0.05) within 3 min of ligation. Finally, cutting the LV free wall from the atrioventricular orifice to the apex (preventing any developed LV free wall force during systole) caused a 45% further decrease in RVDP (N = 2, P < 0.02). Cineradiographic study showed that alterations in RVDP resulting from changes in LV volume and coronary occlusion correlated significantly (N = 5, P < 0.01) with the magnitude of septal bulging into the RV cavity during systole. Alteration in LV free wall function and changes in LV volume may directly effect RVDP through the myocardium.
