CCR5 receptor expression is down-regulated in HIV type 2 infection: implication for viral control and protection.
CCR5 receptor expression is down-regulated in HIV type 2 infection: implication for viral control and protection.
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CCR5 受体表达在 HIV 2 型感染中下调：对病毒控制和保护的影响。
DOI：
10.1089/0889222041217383
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Cao,H
中科院分区：
文献类型：
--
作者：
Shea,A;Sarr,DiengA;Jones,N;Penning,L;Eisen,G;Gueye-Ndiaye,A;Mboup,S;Kanki,P;Cao,H
HIV-2 is known to display an attenuated phenotypein vivowith prolonged time to disease and decreased rate of transmission. Observational studies in Senegal have demonstrated protection from HIV-1 infection, although the putative mechanism for immunoprotection remains undefined. We evaluated HIV-2-seropositive women from a cohort of commercial sex workers in Dakar, Senegal and identified individuals with very low surface CCR5 receptor expression on CD4+T cells.In vitroup-regulation of the CCR5 receptor was readily achieved. Down-regulation of the CCR5 was not correlated with activation markers (HLA-DR), β-chemokine levels, or plasma viral loads. A correlation was observed with HIV-2-specific CD8+T cell activity as measured by intracellular cytokine production. We postulate that down-regulation of the CCR5 receptor in HIV-2 infection contributes to slower disease course and to the protective mechanism against HIV-1 superinfection, mediated in part by HIV-2-specific cellular immune responses.
