Chemogenetics-A Transformational and Translational Platform
Chemogenetics-A Transformational and Translational Platform
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DOI：
10.1001/jamaneurol.2015.1921
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发表时间：
2015-11-01
期刊：
影响因子：
29
通讯作者：
Roth, Bryan L.
中科院分区：
文献类型：
--
作者：
English, Justin G.;Roth, Bryan L.
神经系统疾病通常是由于神经元和神经胶质细胞的电信号和/或化学信号传导不当造成的。最终的补救措施将需要重新编程这些信号。从历史上看，纠正神经元和神经胶质信号是通过药物治疗/给药来完成的，尽管它们经常不能有效和充分地治疗潜在的疾病。基础研究的发展已经产生了几种新的潜在治疗方法，可以在单细胞水平上直接和精确地控制神经元的活动。我们回顾了一种这样的技术，由设计药物独家激活的设计受体，并提出了它作为增强神经元和胶质信号和活性的强大工具的潜力，用于基础和转化应用。
Neurologic disorders are frequently a result of inappropriate electrical and/or chemical signaling of neurons and glia. Ultimate remediation would necessitate reprogramming these signals. Historically, correcting neuronal and glial signaling is accomplished via drug therapy/administration, although they frequently fail to effectively and fully treat the underlying disorder. Developments in basic research have produced several new classes of potential therapeutics to directly and precisely control neuron activity at the single-cell level. We review one such technology, Designer Receptors Exclusively Activated by Designer Drugs, and suggest its potential as a powerful tool for augmenting neuronal and glial signaling and activity for basic and translational applications.