Mortality among workers employed in the titanium dioxide production industry in Europe
Mortality among workers employed in the titanium dioxide production industry in Europe
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DOI：
10.1023/b:caco.0000036188.23970.22
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发表时间：
2004-09-01
影响因子：
2.3
通讯作者：
Weiderpass, E
中科院分区：
文献类型：
--
作者：
Boffetta, P;Soutar, A;Weiderpass, E
目的：评估与二氧化钛（TiO（2））职业暴露相关的肺癌死亡风险。方法：对欧洲11家TiO（2）生产工厂的15，017名工人（14，331名男性）进行死亡率随访研究。暴露于TiO（2）粉尘重建每个职业头衔，暴露估计与职业史。观察到的死亡率与国家率进行比较，内部比较是基于多变量考克斯回归analysis.Results：该队列贡献了371,067人年的观察（3.3%失访和0.7%移民）。2652名队列成员在随访期间死亡，男性标准化死亡率（SMR）为0.87（95%CI 0.83-0.90），女性为0.58（95%CI 0.40-0.82）。在男性中，肺癌的SMR显著增加（1.23，95%CI 1.10-1.38）;然而，肺癌死亡率并不随工作时间或估计的TiO（2）粉尘累积暴露而增加。三分之一以上的群组成员有吸烟数据。在三个国家，吸烟者的患病率是较高的队列成员相比，全国population.Conclusions：研究结果并不表明二氧化钛（2）粉尘对人类肺部的致癌作用。
Objectives: To assess the risk of lung cancer mortality related to occupational exposure to titanium dioxide (TiO(2)).Methods: A mortality follow-up study of 15,017 workers (14,331 men) employed in 11 factories producing TiO(2) in Europe. Exposure to TiO(2) dust was reconstructed for each occupational title; exposure estimates were linked with the occupational history. Observed mortality was compared with national rates, and internal comparisons were based on multivariate Cox regression analysis.Results: The cohort contributed 371,067 person-years of observation (3.3% were lost to follow-up and 0.7% emigrated). 2652 cohort members died during the follow-up, yielding standardized mortality ratios (SMRs) of 0.87 (95% confidence interval [CI] 0.83-0.90) among men and 0.58 (95% CI 0.40-0.82) among women. Among men, the SMR of lung cancer was significantly increased (1.23, 95% CI 1.10-1.38); however, mortality from lung cancer did not increase with duration of employment or estimated cumulative exposure to TiO(2) dust. Data on smoking were available for over one third of cohort members. In three countries, the prevalence of smokers was higher among cohort members compared to the national populations.Conclusions: The results of the study do not suggest a carcinogenic effect of TiO(2) dust on the human lung.