A family of murine NK cell receptors specific for target cell MHC class I molecules.
A family of murine NK cell receptors specific for target cell MHC class I molecules.
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DOI：
10.1006/smim.1995.0013
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发表时间：
1995-04-01
影响因子：
7.8
通讯作者：
Smith, H R
中科院分区：
文献类型：
--
作者：
Yokoyama, W M;Daniels, B F;Smith, H R
Ly-49A 分子是一种对靶细胞上 MHC I 类分子具有特异性的 NK 细胞受体。当 Ly-49A 与 H-2Dd 结合时，Ly-49A+ NK 细胞在体外完全无法杀死其靶标。这种相互作用也发生在体内。 Ly-49A 属于高度相关的分子家族，包括也决定 NK 细胞特异性的 Ly-49C（5E6 抗原）和 LGL-1。在 NK 基因复合体中，Ly-49 家族与编码 NKR-P1 和 CD69 的基因存在遗传连锁，这些基因在结构上相关并能够激活 NK 细胞。最后，Ly-49 可能与在 NK 细胞上选择性表达并影响 NK 细胞特异性的人类分子有关。这些发现凸显了 Ly-49 家族在 NK 细胞活性中的新兴重要性。
The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+ NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.