Longitudinal changes of anti-ganglioside antibodies before and after Guillain-Barre syndrome onset subsequent to Campylobacter jejuni enteritis
Longitudinal changes of anti-ganglioside antibodies before and after Guillain-Barre syndrome onset subsequent to Campylobacter jejuni enteritis
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DOI：
10.1016/s0022-510x(03)00029-7
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发表时间：
2003-06-15
影响因子：
4.4
通讯作者：
Hirata, K
中科院分区：
文献类型：
--
作者：
Odaka, M;Koga, M;Hirata, K
抗神经节苷脂抗体经常存在于急性期格林-巴利综合征（GBS）患者的血清中，但没有患者在综合征发作前进行抗神经节苷脂抗体检测的报道。我们描述了第一例GBS随后空肠弯曲菌感染，其中纵向变化的抗神经节苷脂抗体滴度进行了测量之前和之后的发病肢体无力。血清抗GM I（1gM/IgG）、GM 1b（IgM/IgG）、GalNAc-GD 1a（IgM/IgG）和GD 1b（IgG）抗体滴度在发病当天最高，但在发病前为阴性。抗C空肠弯曲菌IgG和伊加抗体滴度超过抗神经节苷脂抗体滴度，表明空肠弯曲菌感染引发抗神经节苷脂抗体产生。Press et a]. [J. Neurol. Sci. 190（2001）41]报道抗神经节苷脂抗体滴度在恢复期达到峰值，但我们的发现与他们的相反。我们推测抗神经节苷脂抗体是GBS神经损伤的主要效应物。(C)2003 Elsevier Science B. V.保留所有权利。
Anti-ganglioside antibodies frequently are present in sera from patients with Guillain-Barre syndrome (GBS) during the acute phase, but no patients in whom anti-ganglioside antibodies were tested before the onset of the syndrome have been reported. We describe the first case of GBS subsequent to Campylobacter jejuni infection, in which longitudinal changes in anti-ganglioside antibody titers were measured before and after the onset of limb weakness. Serum antibody titers against GM I (1gM/IgG), GM1b (IgM/IgG), GalNAc-GD1a (IgM/IgG), and GD1b(IgG) were highest on the day of onset, but negative before onset. Anti-C. jejuni IgG and IgA antibody titers paralleled those of the anti-ganglioside antibodies, indicative that C jejuni infection triggered anti-ganglioside antibody production. Press et a]. [J. Neurol. Sci. 190 (2001) 41] reported that anti-ganglioside antibody titers peaked during the recovery phase, but our findings are counter to theirs. We speculate that anti-ganglioside antibodies are the primary effectors of nerve damage in GBS. (C) 2003 Elsevier Science B.V. All rights reserved.