Regression of murine lung tumors by the let-7 microRNA.
Regression of murine lung tumors by the let-7 microRNA.
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DOI：
10.1038/onc.2009.445
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发表时间：
2010-03-18
期刊：
影响因子：
8
通讯作者：
Slack, F. J.
中科院分区：
文献类型：
--
作者：
Trang, P.;Medina, P. P.;Wiggins, J. F.;Ruffino, L.;Kelnar, K.;Omotola, M.;Homer, R.;Brown, D.;Bader, A. G.;Weidhaas, J. B.;Slack, F. J.
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small cell lung cancer (NSCLC) significantly reduces tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment.
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