Electrochemical treatment of mouse and rat fibrosarcomas with direct current
Electrochemical treatment of mouse and rat fibrosarcomas with direct current
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DOI：
10.1002/(sici)1521-186x(1997)18:1
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发表时间：
1997-01-01
影响因子：
1.9
通讯作者：
Vora, N
中科院分区：
文献类型：
--
作者：
Chou, CK;McDougall, JA;Vora, N
癌症的电化学治疗（ECT）利用直流电在肿瘤中产生化学变化。ECT已被建议作为一种有效的替代局部癌症治疗。然而，方法尚未确立，机制也没有得到很好的研究。进行体内研究以评估ECT对动物肿瘤模型的有效性。将放射诱导的纤维肉瘤皮下植入157只雌性C3H/HeJ小鼠。将较大的mt纤维肉瘤植入34只雌性Fisher 344大鼠。当小鼠的球形肿瘤达到10 mm时，将2至5个铂电极以各种间距和方向插入肿瘤中。试验组中的10只大鼠在其椭圆形肿瘤约25 mm长时接受治疗;电极插入类似于小鼠研究的后期部分，即，两个在底部，两个在中间。第二组的24只大鼠用6或7个电极治疗，当它们的旋转器约20 mm长时;所有电极都插入肿瘤基部。在24只大鼠中，其中12只给药1次，10只给药2次，2只给药3次。小鼠和大鼠的所有治疗肿瘤均显示坏死和消退;然而，后期肿瘤复发降低了长期存活率。当进行多种治疗时。3个月小鼠肿瘤治愈率最高为59.3%，6个月大鼠肿瘤治愈率最高为75.0%。这些初步结果表明ECT对放射诱导的纤维肉瘤（RIF-1）小鼠肿瘤和大鼠纤维肉瘤有效。有效性取决于电极放置和剂量。(C)1997 Wiley-Liss，Inc.
Electrochemical treatment (ECT) of cancer utilizes direct current to produce chemical changes in tumors. ECT has been suggested as an effective alternative local cancer therapy. However, a methodology is not established, and mechanisms are not well studied. In vivo studies were conducted to evaluate the effectiveness of ECT on animal tumor models. Radiation-induced fibrosarcomas were implanted subcutaneously in 157 female C3H/HeJ mice. Larger mt fibrosarcomas were implanted on 34 female Fisher 344 rats. When the spheroidal tumors reached 10 mm in the mice, two to five platinum electrodes were inserted into the tumors at various spacings and orientations. Ten rats in a pilot group were treated when their ellipsoidal tumors were about 25 mm long; electrode insertion was similar to the later part of the mouse study, i.e., two at the base and two at the center. A second group of 24 rats was treated with six or seven electrodes when their turners were about 20 mm long; all electrodes were inserted at the tumor base. Of the 24 rats, 12 of these were treated once, 10 were treated twice, and 2 were treated thrice. All treated tumors showed necrosis and regression for both mice and rats; however, later tumor recurrence reduced long-term survival. When multiple treatments were implemented. the best 3 month mouse tumor cure rate was 59.3%, and the best 6 month rat tumor cure rate was 75.0%. These preliminary results indicate that ECT is effective on the radiation-induced fibrosarcoma (RIF-1) mouse tumor and rat fibrosarsoma. The effectiveness is dependent on electrode placement and dosage. (C) 1997 Wiley-Liss, Inc.