Confounding effects of heart rate on pulse wave velocity in paced patients with a low degree of atherosclerosis.
Confounding effects of heart rate on pulse wave velocity in paced patients with a low degree of atherosclerosis.
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DOI：
10.1097/01.hjh.0000125447.28861.18
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发表时间：
2004-07-01
影响因子：
4.9
通讯作者：
Hayoz, D
中科院分区：
文献类型：
--
作者：
Haesler, E;Lyon, X;Hayoz, D
背景 脉搏波速度 (PWV) 是动脉壁硬度的指标，受血压 (BP) 调节。心率 (HR) 是否也是 PWV 的调节因素尚存在争议。最近的研究主要涉及高主动脉 PWV 患者，发现两者之间要么没有变化，要么呈正相关。鉴于 PWV 在心血管研究中越来越多地被测量，对于动脉壁弹性保留的患者，应该了解 HR 和 PWV 之间的关系。 目的 本研究的目的是评估 HR 作为轻度动脉粥样硬化患者 PWV 变异性决定因素的重要性。设计和方法 14 名患者（5 名女性，9 名男性；年龄 68±8 岁）因病态窦房结或颈动脉过敏综合征而在起搏器植入后接受评估。在静息时和心房起搏期间以 80、90 和 100 bpm（起搏 HR）测量颈动脉-股动脉 PWV 通过回声多普勒测量动脉股动脉血流量 (AFBF)。 结果 静息窦性心律期间（HR 62 +/- 8 bpm；平均值 +/- SD）PWV 从 6.2 +/- 1.5 m/s（平均 SD）增加到 6.8 +/-起搏速率为 80、90 和 100 bpm 时分别为 1.0、7.0 +/- 0.9 和 7.6 +/- 1.1 m/s (P < 0.0001)。收缩压 (SBP) 和平均血压 (MBP) 在所有 HR 水平下保持恒定，而 AFBF 以线性方式增加。 结论 这些结果表明，即使在动脉粥样硬化程度较低的患者中，HR 也是颈动脉-股动脉 PWV 的潜在调节剂。
Background Pulse wave velocity (PWV), an index of arterial wall stiffness, is modulated by blood pressure (BP). Whether heart rate (HR) is also a modulator of PWV is controversial. Recent research involving mainly patients with high aortic PWV have found either no change or a positive correlation between the two. Given that PWV is increasingly being measured in cardiovascular studies, the relationship between HR and PWV should be known in patients with preserved arterial wall elasticity.Objective The aim of this study was to evaluate the importance of HR as a determinant of the variability in PWV in patients with a low degree of atherosclerosis. Design and methods Fourteen patients (five female, nine male; aged 68 8 years) were evaluated post pacemaker implantation due to sick sinus or carotid hypersensitivity syndromes. Carotid-femoral PWV was measured at rest and during atrial pacing at 80, 90 and 100 bpm (paced HR) Arterial femoral blood flow (AFBF) was measured by echodoppler.Results PWV increased from 6.2 +/- 1.5 m/s (mean SD) during resting sinus rhythm (HR 62 +/- 8 bpm; mean +/- SD) to 6.8 +/- 1.0, 7.0 +/- 0.9, and 7.6 +/- 1.1 m/s at pacing rates of 80, 90 and 100 bpm, respectively (P < 0.0001). Systolic (SBP) and mean blood pressure (MBP) remained constant at all HR levels, whereas AFBF increased in a linear fashion.Conclusions These results demonstrate that even in patients with a low degree of atherosclerosis, HR is a potential modulator of carotid-femoral PWV.