Time-limited buprenorphine replacement therapy for opioid dependence: 2-year follow-up outcomes in relation to programme completion and current agonist therapy status
Time-limited buprenorphine replacement therapy for opioid dependence: 2-year follow-up outcomes in relation to programme completion and current agonist therapy status
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DOI：
10.1080/09595230601146603
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发表时间：
2007-03-01
影响因子：
3.8
通讯作者：
Sandvik, Leiv
中科院分区：
文献类型：
--
作者：
Kornor, Hege;Waal, Helge;Sandvik, Leiv
方案的完成预示着阿片依赖者的治疗后戒断和其他改善，而持续的激动剂治疗比不使用激动剂治疗有更好的结果。这项研究旨在评估9个月丁丙诺啡方案的随访结果、完成情况和当前激动剂治疗状态之间的关系。在75名阿片依赖的前参与者中，有68人在研究开始时和研究后24个月进行了评估。结果衡量指标为阿片类药物戒断、物质使用和心理社会表现。丁丙诺啡方案完成者(n=38)和未完成者(n=30)，以及正在接受激动剂治疗的参与者(n=37)和未接受激动剂治疗的参与者之间进行了组间比较。将随访时的表现与研究开始时的表现进行比较。9人在随访中戒除了所有阿片类药物。完成者和非完成者在随访表现和变化模式上相似，而参与者目前的激动剂治疗状态与物质使用和心理社会结果都有关。无论完成情况和激动剂治疗状态如何，街头阿片类药物的使用和注射都有所减少。随着时间的推移，患者继续接受激动剂替代治疗比完成一个有时间限制的计划更有可能影响长期结果。有时间限制的丁丙诺啡替代疗法似乎不适合阿片类药物依赖者。
Programme completion is predictive of post- treatment abstinence and other improvements in persons with opioid dependence, while continued agonist treatment is associated with better outcomes than no agonist treatment. This study aimed to assess relationships between follow- up outcomes of a 9- month buprenorphine programme, completion and current agonist therapy status. Sixty- eight of 75 opioid- dependent former participants were assessed at study entry and 24 months thereafter. Outcome measures were opioid abstinence, substance use and psychosocial performance. Group comparisons were made between buprenorphine programme completers ( n = 38) and non- completers ( n = 30), and between participants who were currently in agonist therapy ( n = 37) and those who were not. Performance at follow- up was compared to that at study entry. Nine people were abstinent from all opioids at follow- up. Completers and non- completers were similar in follow- up performance and patterns of change, while participants' current agonist therapy status was related to both substance use and psychosocial outcomes. Reductions in street opioid use and injecting were seen regardless of completion and agonist therapy status. Retaining patients in agonist replacement therapy over time is more likely than completion of a time- limited programme to influence long- term outcomes. Time- limited buprenorphine replacement therapy appears to be inappropriate for persons with opioid dependence.