Height, height-related SNPs, and risk of non-melanoma skin cancer
Height, height-related SNPs, and risk of non-melanoma skin cancer
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DOI：
10.1038/bjc.2016.366
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发表时间：
2017-01-03
影响因子：
8.8
通讯作者：
Han, Jiali
中科院分区：
文献类型：
--
作者：
Li, Xin;Liang, Liming;Han, Jiali
背景：成人身高与包括黑色素瘤在内的几种部位特异性癌症的风险相关。然而，较少关注已给予非黑色素瘤皮肤癌（NMSC）。方法：我们前瞻性地研究了鳞状细胞癌（SCC）和基底细胞癌（BCC）的风险与成人身高的护士健康研究（NHS，n= 117 863）和卫生专业人员随访研究（HPFS，n = 51 111）。我们还调查了NHS和HPFS遗传数据集中身高相关遗传标记与BCC和SCC风险之间的关系结果：在控制了潜在的混杂因素后，BCC组3898例，对照组8530例; SCC组527例，对照组8962例身高每增加10 cm与SCC和BCC风险的相关性分别为1.02，1.15（95%CI：1.07，1.13）和1.10（95%CI：1.02，1.15）。没有687高度相关的单核苷酸多态性（SNP）与SCC或BCC的风险显着相关，也没有独立的高度相关locus.Conclusions的遗传分数相结合：我们的数据从两个大的队列提供了进一步的证据表明，高度与NMSC的风险增加。对身高相关的遗传位点和早期暴露的更多研究可能有助于阐明潜在的机制。
Background: Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC).Methods: We prospectively examined the risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in relation to adult height in the Nurses' Health Study (NHS, n= 117 863) and the Health Professionals Follow-up Study (HPFS, n = 51 111). We also investigated the relationships between height-related genetic markers and risk of BCC and SCC in the genetic data sets of the NHS and HPFS (3898 BCC cases, and 8530 BCC controls; 527 SCC cases, and 8962 SCC controls).Results: After controlling for potential confounding factors, the hazard ratios were 1.09 (95% CI: 1.02, 1.15) and 1.10 (95% CI: 1.07, 1.13) for the associations between every 10 cm increase in height and risk of SCC and BCC respectively. None of the 687 height related single-nucleotide polymorphisms (SNPs) was significantly associated with the risk of SCC or BCC, nor were the genetic scores combining independent height-related loci.Conclusions: Our data from two large cohorts provide further evidence that height is associated with an increased risk of NMSC. More studies on height-related genetic loci and early-life exposures may help clarify the underlying mechanisms.