Exercise protects against glucose intolerance in individuals with a small body size at birth
Exercise protects against glucose intolerance in individuals with a small body size at birth
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DOI：
10.1016/j.ypmed.2004.01.035
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Barker, DJP
中科院分区：
文献类型：
--
作者：
Eriksson, JG;Ylihärsilä, H;Barker, DJP
背景。出生时体型小是患2型糖尿病的一个危险因素。我们调查了有规律的运动是否与出生时体型小的个体葡萄糖耐受性降低有关，以及出生时体型是否会影响成年后的运动习惯。500名年龄在65-75岁之间、有出生测量数据的受试者接受了口服葡萄糖耐量试验。他们报告了每周的运动频率和强度以及每年的体育休闲时间活动。频繁（大于或等于每周3次）或适度的每周运动和每年的体育活动都与较低的葡萄糖不耐受率有关。然而，这种影响取决于出生时的体重，在出生时体重较小（出生体重小于或等于3000 g和/或体重指数小于或等于26 kg/m）的受试者中最强(3)。在男性中，运动频率（P = 0.033）和强度（P = 0.030）以及每年的体育活动（P = 0.005）与出生尺寸呈负相关。由于出生体积小而易患2型糖尿病的受试者，通过经常运动可以强有力地防止葡萄糖耐受不良。虽然出生时的小体型与成年后的小肌肉质量有关，但出生时瘦的男性成年后比那些出生时不瘦的男性锻炼得更多。在这些老年研究对象中，这可能表明适者生存。(C) 2004癌症预防研究所和爱思唯尔公司。版权所有。
Background. Small body size at birth is a risk factor for Type 2 diabetes. We investigated whether regular exercise is related to lower rates of glucose intolerance in individuals with a small body size at birth and whether birth size affects exercise habits in adulthood.Methods. Five hundred subjects aged 65-75 years with data on birth measurements underwent an oral glucose tolerance test. They reported their weekly exercise frequency and intensity and yearly physical leisure time activity.Results. Frequent (greater than or equal to3/week) or moderate weekly exercise and yearly physical activity were all related to lower rates of glucose intolerance. This effect was, however, dependent on birth size, being strongest among subjects with a small body size at birth (birth weight less than or equal to3000 g and/or ponderal index less than or equal to26 kg/m(3)). Among men, frequency (P = 0.033) and intensity (P = 0.030) of exercise as well as yearly physical activity (P = 0.005) correlated inversely with birth size.Conclusions. Subjects predisposed to Type 2 diabetes due to a small birth size are strongly protected from glucose intolerance by regular exercise. Although a small body size at birth is related to a smaller muscle mass in adulthood, men born thin exercised more in adulthood than those not born thin. In these elderly subjects this might indicate the survival of the fittest. (C) 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.