Transcriptional regulation and the role of diverse coactivators in animal cells
Transcriptional regulation and the role of diverse coactivators in animal cells
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DOI：
10.1016/j.febslet.2004.12.007
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发表时间：
2005-02-07
期刊：
影响因子：
3.5
通讯作者：
Roeder, RG
中科院分区：
文献类型：
--
作者：
Roeder, RG
真核生物中的转录调控涉及结构和功能上不同的核RNA聚合酶、相应的一般起始因子、基因特异性（DNA结合）调控因子和多种共调控因子，其通过染色质修饰（例如组蛋白乙酰转移酶和甲基转移酶）或更直接地（例如介体）作用以促进前起始复合物的形成和功能。纯化的因子和DNA与重组染色质模板的生化研究提供了深入了解这些因子的作用的性质和机制，包括染色质重塑和preinitiation复合物形成/功能（转录）步骤中的顺序功能的途径，以及在促进这些步骤之间的过渡的可能作用。(C)2004年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Transcriptional regulation in eukaryotes involves structurally and functionally distinct nuclear RNA polymerases, corresponding general initiation factors, gene-specific (DNA-binding) regulatory factors, and a variety of coregulatory factors that act either through chromatin modifications (e.g. histone acetyltransferases and methyltransferases) or more directly (e.g. Mediator) to facilitate formation and function of the preinitiation complex. Biochemical studies with purified factors and DNA versus recombinant chromatin templates have provided insights into the nature and mechanism of action of these factors, including pathways for their sequential function in chromatin remodeling and preinitiation complex formation/function (transcription) steps and a possible role in facilitating the transition between these steps. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.