The sensitivity of dose distributions for organ motion and set-up uncertainties in prostate IMRT
The sensitivity of dose distributions for organ motion and set-up uncertainties in prostate IMRT
复制标题
DOI：
10.1016/j.radonc.2005.06.010
复制
发表时间：
2005-07-01
影响因子：
5.7
通讯作者：
Damen, EMF
中科院分区：
文献类型：
--
作者：
Bos, LJ;van der Geer, J;Damen, EMF
Background and Purpose: To determine the effect of organ motion and set-up uncertainties on IMRT dose distributions for prostate.Methods: For five patients, IMRT techniques were designed to irradiate the CTV (prostate plus seminal vesicles). Technique I delivered 78 Gy to PTV1 (CTV+ 10 mm margin). Technique II delivered 68 Gy to PTV1, and a 10 Gy boost to PTV2 (CTV+an anisotropic margin of 0 to 5 mm). Technique III delivered 68 Gy to PTV1 and simultaneously 78 Gy to PTV2. Uncertainties were simulated using population statistics of organ motion and set-up accuracy. The average TCP (TCPpop) of the CTV and average NTCP (NTCPpop) of the rectal wall were calculated.Results: The planning TCP was a good predictor for TCPpop for Techniques I and II. Technique III was sensitive for geometrical uncertainties, reducing TCPpop by 0.8 to 2.4% compared to planning. NTCPpop was reduced for Technique III by a factor 2.6 compared to Technique I. For all plans, the planning NTCP was strongly correlated with NTCPpop.Conclusions: Dose distributions created with Techniques I and II are insensitive for geometrical uncertainties, while Technique III resulted in a reduction of TCPpop. This reduction can be compensated by a small dose escalation, while still resulting in an NTCPpop of the rectal wall that is lower or comparable to Technique I. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
