A retrospective examination of mosquito infection on humans infected with Plasmodium falciparum
A retrospective examination of mosquito infection on humans infected with Plasmodium falciparum
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DOI：
10.4269/ajtmh.2003.68.366
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Jeffery, GM
中科院分区：
文献类型：
--
作者：
Collins, WE;Jeffery, GM
对1940年至1963年收集的关于蚊子感染恶性疟原虫的档案资料进行了回顾性研究。患者正在接受疟疾疗法治疗神经梅毒。共检测四斑按蚊和按蚊913批。对173例患者进行了白蛉喂养。寄生虫血症持续200天以上的少数患者继续发生苔藓虫感染。蚊子感染的主要时期发生在配子体血症的前20天。在此期间喂养的311批蚊子中，有209批（67.20%）被感染，其中163批中超过50%的蚊子感染了至少一个卵囊。在配子体血症的继发期，372批蚊虫中有293批（78.76%）被感染。在配子体密度达到峰值前4天至4天，蚊子感染的百分比最高。苔藓虫感染率与在切除脾脏的Aotus猴实验性感染恶性疟原虫的研究中观察到的感染率相似。
A retrospective examination was made of archival data collected between 1940 and 1963 on the infection of mosquitoes with Plasmodium falciparum. Patients were undergoing malariatherapy for the treatment of neurosyphilis. A total of 913 lots of Anopheles quadrimaculatus and An. albimanus were fed on 173 patients. Mosquito infection continued to occur in a few patients beyond 200 days of patent parasitemia. The primary period of mosquito infection occurred during the first 20 days of gametocytemia. Of the 311 lots of mosquitoes fed during this period, 209 (67.20%) were infected, and of these, 163 had greater than 50% of the mosquitoes in the lots infected with at least one oocyst. During secondary periods of gametocytemia, 293 (78.76%) of 372 lots of mosquitoes were infected. The highest percentages of mosquitoes were infected from four days before to four days following peak gametocyte density. Mosquito infection rates were similar to those seen in studies with splenectomized Aotus monkeys experimentally infected with P. falciparum.