DETERMINATION OF DIGESTA FILL AND PASSAGE RATE FROM NONABSORBED PARTICULATE PHASE MARKERS USING THE SINGLE DOSING METHOD
DETERMINATION OF DIGESTA FILL AND PASSAGE RATE FROM NONABSORBED PARTICULATE PHASE MARKERS USING THE SINGLE DOSING METHOD
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DOI：
10.1139/z89-071
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发表时间：
1989-02-01
影响因子：
1.4
通讯作者：
WHITE, RG
中科院分区：
文献类型：
--
作者：
HOLLEMAN, DF;WHITE, RG
给出了一种分析颗粒消化标记物数据的方法，包括粪便填充量、粪便排出量和粪便通过时间。该方法将Stewart-Hamilton原则应用于从单次标记物给药后粪便采样获得的数据;它假设了Alcosta的稳态条件，但没有假设Alcosta的区室化。数据分析与羊的实验中，使用的粒子相标记，铈-141氯化物。 获得的粪便排出量的估计值为1.8 ±。2.2%（平均百分比差异±。SE）大于实际粪便排出量;总粪便填充的体内估计值为3.3 ±。比测量的Crista填充少3.4%。为了进行比较，还使用两种已建立的房室模型方法（即非时间依赖性和时间依赖性二房室模型）分析了当前数据。从Stewart-Hamilton方法和房室模型获得的估计参数之间的唯一显著差异是通过时间依赖性模型估计的通过时间显著缩短。
A method is given for analyzing particulate digestive marker data in terms of digesta fill, fecal output, and digesta passage times. The method applies the Stewart-Hamilton Principle to data obtained from a single marker dosing followed by feces sampling; it assumes steady-state conditions for the digesta, but makes no assumptions concerning compartmentalization of digesta. Data analyses are presented for an experiment with sheep in which a particle phase marker, cerium-141 chloride, was used. The estimate of fecal output obtained was 1.8 .+-. 2.2% (mean percent difference .+-. SE) greater than the actual fecal output; the in vivo estimate of total digesta fill was 3.3 .+-. 3.4% less than measured digesta fill. For comparison, the present data were also analyzed using two established compartment modeling approaches, namely a time-independent and a time-dependent two-compartment model. The only significant difference between the estimated parameters as obtained from the Stewart-Hamilton method and the compartment models was a significantly shorter transit time as estimated by the time-dependent model.