Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer
Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer
复制标题
Circ0004390通过海绵miR-198促进卵巢癌细胞增殖
DOI：
10.1016/j.bbrc.2020.03.024
复制
发表时间：
2020-05-21
影响因子：
3.1
通讯作者：
Wu, Xiaohua
中科院分区：
文献类型：
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作者：
Xu, Fei;Ni, Mengdong;Wu, Xiaohua
环状RNAs(CircRNAs)是一类新的非编码RNAs，在人类疾病和肿瘤进展中发挥重要作用。然而，CircRNAs在卵巢癌中的作用尚不清楚。在这里，我们发现了大量与正常卵巢组织相比在卵巢癌组织中差异表达的CircRNA。我们进一步鉴定了一个源自LPAR3基因的CircRNA，命名为Circ0004390，它在卵巢癌组织中频繁上调。Circ0004390基因敲除可显著降低卵巢癌细胞的增殖。我们进一步证明Circ0004390可能通过充当miR-198家族的海绵来调节卵巢癌细胞MET的表达，从而促进细胞增殖。Circ0004390水平与卵巢癌患者的总体生存密切相关。我们的发现提示Circ0004390通过miR-198/MET轴调控卵巢癌的增殖，这可能为卵巢癌的治疗提供一个潜在的靶点。(C)2020作者。由爱思唯尔公司出版。
Circular RNAs (circRNAs) are a novel class of non-coding RNAs which play important roles in human diseases and tumor progression. However, the function of circRNAs in ovarian cancer remains to be uncovered. Here we found a large amount of circRNAs that are differentially expressed in ovarian cancer tissues compared with normal ovarian tissues. We further identified one circRNA derived from the LPAR3 gene and termed Circ0004390, which was frequently upregulated in ovarian cancer tissues. The knockdown of Circ0004390 can significantly reduce the proliferation of ovarian cancer cells. We further demonstrated that Circ0004390 may promote cell proliferation by acting as a sponge for the miR-198 family to regulated the MET expression in ovarian cancer cells. The level of Circ0004390 was closely related with overall survival of ovarian cancer patients. Our findings suggested that Circ0004390 regulated ovarian cancer proliferation by miR-198/MET axis, which might provide a potential target for the treatment of ovarian cancer. (C) 2020 The Authors. Published by Elsevier Inc.